Showing 3 results for Insulin Resistance
Farvid Ms, Siasi F, Jalai M,
Volume 64, Issue 10 (10-2006)
Abstract
Background: The present study designed to assess the effect of Mg+Zn, vitamin C+E, and combination of these micronutrients on glycemic control and insulin resistance in type 2 diabetic patients
Methods: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months group M: 200 mg and 30 mg Zn (n=16), group V: 200 mg vitamin C and 150 mg vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18).Fasting blood glucose, fructosamine, HbA1c and serum insulin were measured at the beginning and at the end of 3 months supplementation. Insulin resistance was calculated by HOMA score. Treatment effects were analyzed by general linear modeling.
Results: After 3 months of supplementation fasting blood glucose decreased in MV group (165±46 vs 177±41 mg/dl, p=0.035). There was no significant change in fructoseamin, HbA1c, serum insulin or insulin resistance in treatment groups.
Conclusion: The results of the present study provide evidence for the effects of combination of Mg, Zn and vitamin C and E supplementations on improvement of fasting blood glucose but not fructosamine, HbA1c, serum insulin or insulin resistance in type 2 diabetic patients.
Mahmoud Nikseresht , Hamid Rajabi , Ali Nikseresht ,
Volume 73, Issue 5 (8-2015)
Abstract
Background: Apelin is an adipokine which may contribute to the link between obesity and metabolic diseases. Regular exercise training has been proposed as a strategy for reducing the risk of these diseases by positive adaptations in adipokines, but there is limited research directly comparing different types of training. The purpose of this study was to determine and compare the effects of nonlinear resistance training (NRT) and aerobic interval training (AIT) on serum levels of apelin-13 and insulin resistance in middle-aged obese men.
Methods: This quasi-experimental study was conducted from October to February 2012 in Ilam City, Iran. Eligible subjects (33 obese men) between aged 34-46 years participated in this study and were allocated to the following groups: NRT (n= 12), AIT (n= 10), and control (n= 11). The inclusion criteria were sedentary (less than 60 minutes physical activity per week), nonsmokers, no regular exercise for at least the past 6 months, no regular consumption of medication, no special diet, percentage body fat > 23% and no history of medical conditions that would prevent them from participating in the exercise intervention. Only the subjects who performed more than 90% of the training sessions were included in this study. The experimental groups performed 3 weekly sessions for 12 weeks, whereas the control group maintained a sedentary lifestyle. NRT consisted of 40-65 minutes of weight training at different intensities and with a flexible period. AIT consisted of running on a treadmill (4×4 min at 80-90% maximal heart rate, 3 min recovery intervals).
Results: Analysis of variance showed that there were no significant differences betwee n the groups for apelin-13 and insulin resistance at baseline (P> 0.05). Compared to control group, two exercise programs were equally effective at reducing insulin resistance, but apelin-13 levels increased significantly only with the AIT (P= 0.04). After the training, maximal oxygen uptake increased significantly in AIT and NRT compared with control group (both P= 0.001) and in AIT more than NRT (P= 0.001).
Conclusion: The practical applications indicate that obese men can use both AIT and NRT exercise programs to reduce insulin resistance. However, the AIT may have better beneficial effects (as indicated by apelin-13) compared to NRT.
Bahloul Ghorbanian , Fariba Shokrollahi ,
Volume 75, Issue 4 (7-2017)
Abstract
Background: Paraoxonase-1 (PON1) is one of the most important enzymes for removal of the free radicals, and the main protective factor for lipoproteins against oxidative agents. The purpose of this study was to investigate the effects of eight weeks’ rope training on paraoxonase-1 enzyme, insulin resistance and lipid profiles in inactive overweight and obese girls.
Methods: This quasi-experimental study was conducted in Iranian Azarbaijan Shahid Madani University of Tabriz, from November 2016 to January 2017. In this study, 20 healthy overweight and obese in-active girls (20-25 Yr) volunteered and randomly assigned into exercise (n=10) and control (n=10) groups. Exercise protocol was rope training was 8 week for 4 day per week in 45 minute per day. Some anthropometric indexes of subjects were measured before and after exercise. A fasting blood sample was collected as pre-test and post-test, followed by 48 hours of physical inactivity to measure serum levels of PON1 enzyme, Insulin, lipid profiles and other blood variables. Analysis of the data was performed by paired and independent samples t-tests by using the SPSS software, version 20 (IBM, Armonk, NY, USA). The criterion of statistical significance was set as P<0.05.
Results: The paired samples t-test results showed that after exercise intervention, in exercise group, the values of all variables (except low-density lipoprotein) were significantly changed. Also, to compare with control group, the values of PON1 enzyme (P=0.024) and maximum oxygen consumption (P=0.006) significantly increased and insulin resistance index (P=0.028), triglyceride (P=0.046) and body fat percent (P=0.001) were significantly decreased (P<0.05).
Conclusion: The results of this study showed that performing rope training for 8 weeks induced positive changes in paraoxonase-1 enzyme, insulin resistance index, maximum oxygen consumption and some lipid and anthropometric indices in overweight and obese young girls. Therefore, according to these results, rope training, as an aerobic activity it can be useful for all people especially in overweight and obese to control blood fats, body composition and prevent diseases due to obesity such as cardiovascular disease.
