Showing 5 results for Leptin
Rahimi A, Maziar S, Ahmadi F, Shahriari S, Fattahi F, Jam S, Moradmand Badie B, Kourorian Z,
Volume 66, Issue 9 (12-2008)
Abstract
Background: Anemia is a common complication accompanied by high morbidity and mortality in hemodialysis patients. Considering the fact that the reduction of erythropoietin (EPO) synthesis is the main cause of uremic anemia, receiving recombinant human erythropoietin (rHuEPO) can improve the condition in these patients. Some of these hemodialysis patients, however, have acceptable hemoglobin levels without any need to EPO. Higher BMI, higher albumin and leptin plasma levels and longer durations of hemodialysis are possible factors contributing to the reduced need for rHuEPO in these patients. The present study is designed to asses the relationship between the plasma levels of leptin and the reduced EPO need.
Methods: Fifty eligible hemodialysis patients with hemoglobin levels higher than 11 mg/dl were enrolled in the cross-sectional study. The information on age, sex, hemodialysis duration and the cause of renal dysfunction were extracted from the files. The baseline plasma levels of Leptin and albumin were measured. The patients BMI and the weekly need for rHuEPO were also calculated.
Results: There was no correlation between the weekly need for rHuEPO and sex, BMI, the cause of renal dysfunction and the plasma levels of albumin and leptin it, however, was related with age and the duration of dialysis. While age negatively influences the weekly need, the duration of dialysis has a positive effect on the need.
Conclusion: The plasma levels of leptin are not directly correlated with the required amounts of rHuEPO, indicating that leptin is not an effective factor in erythropoiesis. Conversely, older age and shorter hemodialysis durations are accompanied by reduced need for rHuEPO.
Marsoosi V, Mortazavi M, Zakeri Hr, Jamal A,
Volume 67, Issue 7 (10-2009)
Abstract
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Background: The mechanisms by which fetal weight are regulated during pregnancy
are poorly understood. The relation between hormones such as leptin and adiponectin and intrautrine growth is still
under investigation. The aim of this study was to ascertain whether fetal
growth restriction is associated with alterations of leptin and adiponectin concentrations
in venous umbilical cord blood and maternal serum.
Methods: Maternal serum and venous umbilical cord blood leptin
and adiponectin concentrations were determined by ELISA after 36 week of
gestational age in 22 women with uncomplicated singleton pregnancies with AGA fetuses
(group A) and in 22 women with singleton pregnancies complicated by fetal
growth restriction but without fetal distress (group B), all with
normal body mass index and without history of diabetes, hypertention or
maternal cardiac disease.
Results: Venous umbilical cord leptin levels were significantly
lower in group B compared with group A (8.1±0.8ng/ml versus 39.45±6.8ng/ml p=0.001). Venous
umbilical cord adiponectin levels were also significantly lower in group B compared with
group A
(28.8±3.5μg/ml versus 43.6±3.7μg/ml p=0.007). Maternal serum leptin and adiponectin did not differ
between SGA and AGA groups.maternal BMI, gestational age and maternal age did not differ
between these two groups. Neither leptin nor adiponectin correlated with gender
difference.
Conclusion: In this study we confirmed that growth restricted
fetuses show venous umbilical cord blood leptin and adiponectin concentrations
were significantly lower than those in normal fetuses indicating that these two
adipokines have an independent role in growth restriction pathogenesis. Maybe
in future we can administer recombinant human leptin and adiponectin to growth
restricted fetuses for treatment.
Rashidlamir A, Saadatnia A,
Volume 69, Issue 2 (5-2011)
Abstract
Background: Obesity is currently a worldwide health epidemic which has incited major interest among researchers to look for the underlying mechanisms that regulate body weight. In fact, adiponectin and leptin concentrations that are called adipokines are altered in obesity with a decreased production of adiponectin and an increased production of leptin. Adiponectin has anti-inflammatory, anti-atherosclerotic and anti- insulin resistance properties, but increased levels of leptin are observed in patients with diabetes and cardiovascular diseases. The aim of the present study was to investigate the effects of an 8-week aerobic training program on the plasma levels of adiponectin and leptin in healthy middle-aged men.
Methods: Thirty healthy middle-aged men were selected based on their body fat percentage and were assigned to two equal groups. The experimental group took the 8- week training, four days a week on alternate days with an intensity of 60-80% of their heart rate reserve but the control group lived their sedentary life. Blood samples were collected before and after the training program from all subjects and plasma adipokine levels were measured.
Results: Plasma adiponectin concentration increased while leptin levels decreased significantly (P<0.001 and P≤0.042 respectively) upon completion of the 8-week program. Moreover, reduction in body fat percentage (P≤0.001) negatively correlated with adiponectin (P≤0.001) and positively with leptin changes (P≤0.008).
Conclusion: In healthy middle-aged men, 8-week aerobic training programs could reduce body fat percentage and improve plasma adipokines levels. Therefore, aerobic training can be considered as a major strategy for preventing obesity and its
accompanying diseases.
Sara Rostami, Leila Kohan, Mohammad Mohammadian Panah, Fereshteh Fereiduni,
Volume 72, Issue 6 (9-2014)
Abstract
Background: Leptin is an adipokine made by fat cells and plays a key role in proliferation, cell survival, migration and immune response. Several studies have suggested that individuals with high serum leptin concentrations would increase the risk of breast cancer. G -2548A polymorphism in the leptin gene is located in the promoter region and is associated with the change of leptin serum level. In this study, the association between G -2548A polymorphism in leptin gene and breast cancer susceptibility was investigated.
Methods: This case-control study was done on 374 Iranian women. This study was performed from March 2013 to February 2013. Blood samples from 203 women with breast cancer and 171 age (±5)- matched healthy women were collected. Breast cancer patients were selected from Namazi Hospital in Shiraz city. Genomic DNA was extracted from blood samples. The G -2548A polymorphism of leptin gene was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Data analysis was performed by SPSS version 18. Logistic regression analysis was used for association of breast cancer susceptibility and G -2548A polymorphism of leptin gene.
Results: The A allele frequency was 60% in control group and 72% in breast cancer patients. There was a significant association between A allele in -2548 position of leptin gene and breast cancer susceptibility (OR: 1.8, 95% CI: 1.3-2.4, P<0.001). In the reces-sive effect of the A allele (comparison between AA vs. AG+GG), AA genotype in -2548 region of leptin promoter sequence was significantly increased the risk of breast cancer (OR=2.2, 95% CI: 1.5-3.4, P<0.001).
Conclusion: It is concluded that A allele in the -2548 promoter region of leptin gene may act as a recessive allele and increase the breast cancer risk.
Mehdi Asgari , Nozar Dorestan , Neda Najibpour , Changiz Delavari , Mohammad Bahadoram ,
Volume 74, Issue 1 (4-2016)
Abstract
Background: Laparoscopic cholecystectomy is a minimally invasive procedure whereby the gallbladder is removed using laparoscopic techniques. Monopolar electerosurgical energy is the method of dissection of gallbladder from liver bed. Ultrasonic energy causes less thermal damage and suggests an alternative to monopolar elevterocautery. Leptin is a tissue factor and C-reactive protein (CRP) is an acute phase protein that builds up in surgical damages. In laparoscopy, pneumoperitoneum and thermal damage cause this increase. In this study, after completion of surgery with both methods, plasma leptin and CPR were measured. Next, the complications and benefits of the two methods were compared.
Methods: This single blind randomized clinical trial was conducted on 78 patients who were candidate for laparoscopic cholecystectomy in surgery clinic of Razi Teaching Hospital in Ahvaz Jundishapur University of Medical Sciences from March 2013 to March 2015. Patients were divided randomly into two groups of ultrasonic and electerocautery. Then, leptin’s level and CRP’s level were measured at completion of surgery, 30 minutes after completion, 6 and 24 hours after completion of surgery in the two groups.
Results: This study shows that the average rate of leptin at completion of surgery, 30 minutes after completion, 6 and 24 hours after completion of surgery in ultrasonic group had less increase than electerocautery group and the difference was statistically significant (P= 0.0001). The average rate of CRP at completion of surgery, 30 minutes after completion, 6 and 24 hours after completion of surgery in ultrasonic group had less increase than electerocautery group and the difference was statistically significant (P= 0.0001).
Conclusion: The level of leptin and CRP shows that surgery with ultrasonic method will provoke the immune system less than electerocautery method.
