Showing 8 results for Maze
B Behnoosh, A Pajm, F Taghaddosinejad , M Dalirrad,
Volume 64, Issue 1 (3-2006)
Abstract
Background and Aim: Due to the increased usage of carbamazepine, phenytoin and Sodium Valproate, a higher number of intoxication is to be expected. The aim of this Study is demographic evaluation of this agents.
Materials and Methods: In this cross-sectional survey we studied 93 patients who were poisoned with these drugs from July 2003 until July 2004, in Loghman Hakeem hospital, Tehran, Iran.
Results: In this study we found these results: 36.6 % were male and 63.4 % of patients were female mean age of patients were about 24.5 y. twenty nine present (29) % were routinely on these drugs. Mean time between consumption and admission was 6 hours and 56% of them had decreased level of consciousness and 90% had high serum level of drugs. 80% of them showed complications such as respiratory distress, Urinary tract infection and etc and 4.5% of patients admitted in ICU and mortality rate was 2%
Conclusion: Results of this study are compatible with other studies and according to high prevalence of overdose with these drugs we must focus on prevention factors like education for suitable management, good care, psychiatric consult and proper Treatment.
Vaezi Gh, Zarrindast M R, Salarian Zadeh A, Babapour S,
Volume 65, Issue 7 (10-2007)
Abstract
Background: Anxiety is a complex phenomenon with important results. In fact anxiety is a biologic process that has repetitive biological and physiological effect on the biological structure of brine. From long time ago anxiety and fear has bean one of the important psychological issues and for the control of anxiety different drugs with different mechanisms have been presented and understanding mechanisms that are involved lead us to newer drugs discovery. In this research the effect of morphine on the anxiety in the adult Male rats in the Ventral Tegmental area (VTA) and Nucleus Accumbens (NAc) was studied.
Methods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze (OAT %) and the percentage of entries into the open arms (OAE %) to measure anxiety. Increases in the OAT% and OAE% indicate an anxiolytic effect (reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. Adult male rats, weighing 200-240 grams, underwent surgery. After five days, the rats were injected with saline and three different doses of morphine (2.5, 5, and 7.5 µl/rat). Experiment one included the injections into the VTA. In the second experiment, these injections were in the NAc. Behavioral tests were conducted between 12 pm and 4 pm and each animal was used once for each experiment.
Results: In the first experiment, although these doses of morphine injected into the TVA had no effect on the OAE%, a dose of 5µl/rat increased the OAT%, showing a decrease in the animals' anxiety. In the second experiment, doses of 2.5µl/rat injected into the NAc induced a significant increase in the OAT% and OAE%, there by displaying decreased anxiety in the animal. However, no significant change in the activity of the animals was observed.
Conclusion: As a Result of these experiments, it seems that different doses of morphine can decrease anxiety, probably through interaction with gabaergic system. |
Mansoori M, Parviz M, Keshavarz M, Soltani N, Gharibzadeh Sh,
Volume 65, Issue 13 (3-2008)
Abstract
Background: Diabetes mellitus is a common metabolic disorder accompanied with
structural and functional changes in central and peripheral nervous system. Researches
showed, memory disturbance were occurred in the course of diabetes. On the other hand,
magnesium deficit has been described in diabetic patients. Some researches were showed
that, appropriate magnesium supplementation can play a positive role in diabetic control.
Methods: Locally produced male rats were used. Diabetes was induced with intravenous
injection of 40 mg/kg streptozotosin. In treatment groups, the animals were received
magnesium sulfate via drinking water (10 g/l). Eight weeks after diabetes confirmation,
the animals were assessed on Morris Water Maze.
Results: A significant decrease in time of platform finding (latency) and distance of
swimming in all four experimental days were seen in all groups. Mean latency in diabetic
group was significantly higher than the other. This weak response was almost completely
prevented by magnesium sulfate administration.
Conclusion: It seems that after eight weeks magnesium sulfate administration (10g/l),
spatial memory of the animals was improved in comparison to diabetic group that can
suggest role of magnesium in recovery of diabetic animal memory.
Barzegar M, Talaei Zavareh Sa, Salami M,
Volume 68, Issue 10 (1-2011)
Abstract
Background: Numerous evidences indicate that various environmental stresses during
pregnancy affect physiological behavior of the offspring. This experimental
study was designed to investigate the effect of noise stress during prenatal
period of rats on spatial learning and memory and plasma corticostrone level in
postnatal life.
Methods: Three groups of pregnant rats were given daily noise stress with durations of
two and/ or four hours in last week of pregnancy period. The fourth group was
left unstressed. The male offspring from the unstressed and different stressed
groups were assigned as controls and stressed groups. The animals were
introduced to a spatial task in Morris water maze 4
trials/day for five consecutive days. The probe test was performed on the 5th day of the experiment. The delay in findings and the distance passed to locate
the target platform were assessed as the spatial learning.
Results: Our results showed that prenatal exposure to noise stress for two and/ or four
hours a day, leads to impaired acquisition of spatial learning in the postnatal
animals. The plasma level of corticostrone in the two stressed groups of rats
markedly matched with their behavioral function. Prenatal exposure to 1-
hour noise stress revealed no effects on the offsprings' behavior and plasma
corticostrone level.
Conclusion: Based on our study results, it seems that applied range of stress which is
executed through the noise stress could increase the plasma corticostrone level
and could decrease spatial learning and memory of adult male offspring.
Rezaie A, Mosavi Gh, Ahmadizadeh Ch, Jafari B,
Volume 69, Issue 3 (6-2011)
Abstract
Background: Rosa damascene has a special role in the Iranian traditional medicine due to its sedative, anticonvulsant and analgesic effects. Regarding its alkaloid, flavonoid and other organic compounds, this plant has always been used to reduce nervousness and treat depression and chronic insomnia. In the present time, synthetic drugs with sedative and anxiolytic properties are used for such problems but due to their side- effects and economic issues, the significance of natural medicines with fewer side- effects is of interest. Considering the importance of sedative and anxiolytic effects of Rosa damascene, we decided to compare this plant with synthetic drugs of the same properties.
Methods: Two different groups of male Wistar rats received either Rosa damascene extract in doses of 150, 300, 450 mg/kg or Diazepam and dimethyl sulphoxide in doses of 1.2 mg/kg intraperitoneally 30 minutes before assessing the sleep duration, sedation and preanesthetic effects induced by intraperitoneal ketamine, 40 mg/kg. The anti- anxiety effect was evaluated by using an elevated plus maze and a rota rod.
Results: The results showed a meaningful increase in the period of sleep induced by Ketamine (P≤0.01) and also a meaningful increase in time spent at the open arms of the device in the group receiving Rosa damascene extract (P≤0.01).
Conclusion: The results showed that the Rosa damascene extract dose 450mg/kg has sedative, preanesthetic and anxiolytic effects (P≤0.01).
Davari S, Talaei Sa, Soltani M, Alaei H, Salami M,
Volume 70, Issue 9 (12-2012)
Abstract
Background: Diabetes mellitus affects numerous intracellular metabolic processes, which are reflected by changes in the concentration of some plasma constituents. Particularly, the disease may indirectly undermine some functions of the nervous system including learning and memory through altering oxidative stress status. On the other hand, probiotics can enhance the antioxidant capacity. This study was designed to evaluate the effects of probiotics on spatial memory, maze learning and indices of oxidative stress in diabetic rats.
Methods: In this experimental study, 40 male Wistar rats were randomly allocated to 4 groups (n=10 for each): Control (CO), Control probiotic (CP), Control diabetic (DC), and Diabetic probiotic (DP). The probiotic supplement, including Lactobacillus acidophilus, Lactobacillus fermentum, Bifidobacterium lactis (334 mg of each with a CFU of ~1010), was administered through drinking water every 12 hours for 8 weeks. Using morris water maze (MWM), spatial learning and memory were evaluated. Serum insulin and oxidative stress indices, including superoxide dismutase (SOD) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), were measured by standard laboratory kits.
Results: Oral administration of probiotics improved impairment of spatial learning (P=0.008) and consolidated memory (P=0.01) in the rats. Moreover, probiotic treatment increased serum insulin (P<0.0001) and serum superoxide dismutase activity (P=0.007) while it decreased their blood glucose (P=0.006) and 8-OHdG (P<0.0001).
Conclusion: Probiotic supplementation reversed the serum concentrations of insulin and glucose along with an increase in antioxidant capacity in diabetic rats. It also improved spatial learning and memory in the animals. Relevancy of the metabolic changes and behavioral functions need to be further studied.
Safari H, Miladi Gorji H,
Volume 70, Issue 11 (2-2013)
Abstract
Background: Previous studies indicate that morphine dependent and withdrawal from chronic opiates enhanced anxiety-related behaviours in novel and stressful conditions in rats. Recent studies have shown that exposure to a stressor generates a wide variety of adaptive responses, while enhancing abilities to adopt with the stressor. Therefore, the aim of this study was to examine the effect of chronic restraint stress and acute water immersion (WI) stress on the anxiety profile in morphine-dependent rats.
Methods: Thirty two rats were injected with twice daily doses (10 mg/kg, subcutaneous, at 12 hour intervals) of morphine over a period of 10 days in the presence or absence chronic restraint stress (1 hour/day). On day 11, two hour after morphine injection, anxiety-like behaviours were tested in the elevated plus-maze model in the presence or absence acute water immersion stress. Rats were divided into four groups: dependent- No restraint stress (D/NRS), dependent- restraint stress (D/RS), dependent- restraint stress+ water immersion stress (D/RS+WI), dependent- water immersion stress (D/WI).
Results: Finding have shown that D/RS+WI rats exhibited an increase in the elevated plus-maze open arm entries and time as compared with the control groups (P=0.018 and P=0.037, respectively). Also, this measure was significantly lower in the WI rats than the D/RS+WI rats (P=0.049 and P=0.031, respectively).
Conclusion: Our findings indicate that chronic restraint stress followed by acute water immersion stress decreases the severity of the anxiogenic-like behaviours in morphine dependent rats thus it may have a therapeutic application in the treatment of the asso-ciated disorders in addiction.
Kohzad S, Bolouri B, Nikbakht F,
Volume 70, Issue 12 (3-2013)
Abstract
Background: Extremely low frequency (0-300 Hz) fields from power lines, electronic equipment and medical devices, have been reported to produce various biological effects. Global system for mobile (GSM) is most largely used in everybody's life. This system utilizes a low frequency band as well as a high frequency range of electromagnetic field. This study investigated the effects of 217 Hz electromagnetic field (the modulating signal in GSM) on spatial learning and memory in rat.
Methods: Twenty four male Wistar rat (200- 250 g) were randomly divided in to three groups as: test, sham and control. Using a Helmholtz coil system, the test group was exposed to a uniform pulsed EMF of 200 µT (micro Tesla) intensity for 4 h/day for 21 days (2 time in a day). This procedure was repeated for the sham group but with no field. All groups were trained prior to the day 21 on the 15th day for five days four trial per day in Morris Water-Maze system. Then the probe test was carried out for 60 seconds with no platform.
Results: The ANOVA test revealed that no significant differences were found between control and exposed rats in all day of learning acquisition. Also, in probe test for investigating the memory, no significant differences observed. (P≤0.05 is accepted for significant level.
Conclusion: This finding is in consistent with previous studies and indicates low frequency band of electromagnetic fields (EMF) (200 µT intensity) in cell phone may not have any effect on the learning acquisition and spatial memory in rat.
