Showing 3 results for Opium
Baigmohammadi Mt, Mohammadi M, Mahmoodpour A, Karvandian K, Aghdashi M,
Volume 66, Issue 7 (10-2008)
Abstract
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Background: Lead poisoning could be associated with
gastrointestinal renal, hematologic complications and neurologic deficit.
Case report: The patient was an opium addict, forty
one years old male, to hospital admitted with gastrointestinal signs,
constipation, abdominal pain, severe weakness of upper and lower limbs without
any sensory impairment and with anemia, leukocytosis, and slightly increased
liver function tests. Serum level of lead was more than 200µg/dl.
After treatment with dimercaprol (BAL),
CaNa2EDTA
for two five days sessions that followed with oral succimer for three days,
signs and symptoms relieved, all laboratory tests became normal and blood level
of lead reduced but the patient was discharged with quadriplegia. There was no
fecal or urinary incontinence.
Conclusions: Because of irreversibility and severity of lead related neuronal injury,
we should suspect to lead poisoning in each patient with neuronal involvement
and concurrent GI and hematologic signs.
Bahman Malek , Roya Seghlis , Ali Dabbagh ,
Volume 67, Issue 10 (1-2010)
Abstract
Background: There are a number of reports regarding awareness during anesthesia and its risk factors. The aim of this study was to assess the frequency of awareness in elective abdominal surgery in opium abusers compared with non-abusers.
Methods: In a cross-sectional descriptive-analytical study, 120 patients were selected and were divided into two groups, opium addicts and non addicts, 60 patients in each. The patients were compared regarding clinical criteria during anesthesia. They were reviewed regarding the content of their answers to the study questionnaire, after a time interval of 24 hours postoperatively (after the surgery). To evaluate the awareness status after general anesthesia, a clinical assessment checklist was used and also, two questionnaires were used. These questionnaires were composed of open ended questions and were administered by one of the colleagues (they were not self administered questionnaires to increase the appropriateness of the answers)
Results: There was no differences between the two research groups regarding basic study variables (p>0.05). The clinical findings and the results of the interviews demonstrated more awareness in the opium abusers (p<0.001).
Conclusions: This study demonstrated a higher chance of awareness in the opium abusing patients when undergoing general anesthesia for the surgical operations involving the abdominal area. This study mentioned that a history of opium abuse can be added as a risk factor for awareness to the previous risk factors.
Saeed Nouri , Anahita Zoghi , Mohammad Reza Sharif , Najla Farhang , Maziar Shojaei ,
Volume 76, Issue 7 (10-2018)
Abstract
Background: Each toxic agent results in unique presentations, depending on what neurophysiological changes occur following exposure. Scientific understanding of lead toxicity in the organ systems and at low levels of exposure continues to evolve. However, effects of lead poisoning on the thyroid gland function are controversial. In this descriptive study, changes in thyroid hormones in patients with lead poisoning were compared with patients with opioid addiction and healthy individual who were matched for age and sex.
Methods: In this descriptive study, which was conducted from March 2016 to February 2017 in Loghman Hakim Hospital in Tehran, ninety patients were evaluated using convenient sampling method for lead and thyroid hormones levels. The levels of lead and thyroid hormones were evaluated using standard laboratory method, in thirty male patients with lead poisoning, thirty male patients with opioid addiction referring to addiction treatment center and thirty healthy male referring to a blood donation center who were matched for age. Thyroid function parameters in patients with lead toxicity were compared with those of control groups.
Results: The lead level in the lead toxicity group was 57.5±23.5 µg/dl, in the first control group with opium addiction 7.8±3.8 µg/dl and in the healthy male referring to a blood donation center, 5.9±9 µg/dl. Thyroid stimulating hormone (TSH) was significantly lower in patients with lead poisoning (0.2±0.01 Milli-International Units Per Liter (mIU/L) than in the patients with opioid addiction (2.4±1/05 mIU/L) and healthy male referring to a blood donation center (2.3±0.01 mIU/L) (P= 0.04), and thyroxine hormone (T4) was significantly higher in patients with lead poisoning (17.8±2.6 µg/dl) than in the patients with opioid addiction (8.8±1/9 µg/dl) and healthy male referring to a blood donation center (7.4±3.5 µg/dl) (P= 0.02).
Conclusion: Lead toxicity has an effect on thyroid function and it reduces thyroid stimulating hormone and increases thyroxin levels. Clinicians should be aware of the potential hazardous effects of lead on the thyroid and mechanisms through which lead causes these effects on thyroid function need to be elucidated.
