Showing 7 results for Osteoporosis
Hajimahmoodi M, Sadeghi N, Hadjibabaie M, Jannat B, Jamshidi Ar, Mirabzadeh M,
Volume 65, Issue 1 (3-2008)
Abstract
Background: The cause of osteoporosis is multifactorial and many dietary factors are important in the prevention of this disease. Antioxidants as free radical scavengers may influence osteoporosis by reducing the effects of oxidative stress that may be associated with bone loss. Vitamin E is an important antioxidant that protects polyunsaturated fatty acids (PUFA) in cell membranes from oxidation. There are only two studies regarding vitamin E plasma levels in subjects suffering from osteoporosis. The purpose of this study was to investigate the association between plasma vitamin E levels and bone mineral density (BMD) in Iranian patients.
Methods: Subjects were consecutively recruited between May and September 2005 from among a total of approximately 1000 people referred for instrumental screening for osteoporosis to the Jami Clinic in Tehran. Inclusion criteria for the study group were: a femoral neck T-score of -1 or less, osteopenia, severe osteopenia and osteoporosis. A total of 137 subjects were enrolled. According to their femoral and spinal BMD scores, 54 persons were selected as a control group. The control group consisted of subjects with a femoral neck T-score and spine T-score of -1 or more. In selecting the case group, only the femoral BMD score was used. Plasma vitamin E was measured, after extraction with methanol, by HPLC with UV detection at 280 nm. Methanol, deionized water and butanol (90:4:6) was used as a mobile phase with a C8 column. The flow rate was 1.0 ml. min-1 and the acetate ester of vitamin E was used as an internal standard.
Results: The results show no significant difference in plasma vitamin E between the control and case groups, however linear regression analysis does reveal a significant difference between the T-score and plasma vitamin E.
Conclusion: Deceleration Femoral bone Density during osteoporosis will be Accelerated with Decrease of Vitamin E Antioxidant level.
Esfahani A, Iravani M, Khoshnyat M, Ghoreishi Z, Shamshiri A R, Moghadam Z, Jahani M, Ghavamzadeh A,
Volume 65, Issue 5 (8-2007)
Abstract
Background: Bone marrow transplantation (BMT) is the treatment of choice for many patients with malignant and nonmalignant diseases. Long-term complications such as osteoporosis should be considered, because it is directly associated with the morbidity and mortality. The purpose of this study is to assess the bone mineral density after allogenic or autologous bone marrow transplantation in patients with leukemia or lymphoma.
Methods: We prospectively investigated 63 patients undergoing BMT for acute and chronic leukemia and lymphoma. At the end of the study, a total of 28 patients were assessed. Bone mineral density (BMD) was measured prior BMT, and 6 and 12 months after BMT. Osteocalcin, bone alkaline phosphatase and C-terminal telopeptides of type 1 collagen (ICTP) were assessed. Serum concentration of calcium, phosphorous, vitamin D, PTH and sex hormones (FSH, LH, testosterone and estradiol) were also measured.
Results: There was a significant decrease in the bone mineral density of the femoral neck six months after BMT (p<0.001), 1.01±0.13g/cm² prior to BMT and 0.96±0.13 g/cm² at six months, but no considerable changes were seen in lumbar vertebrae. Bone loss between the 6th and 12th months was not observed. The levels of ICTP and phosphorus increased significantly by the 12th month (p=0.04). The level of calcium was higher at the 6th month (p=0.002) but the level of vitamin D and PTH decreased by the end of the study (p=0.04 and p=0.01, respectively) and the average of osteocalcin did not increase significantly. In women, the level of estradiol decreased by the 6th month (p=0.01), but the testosterone changes were not significant.
Conclusion: The risk of bone loss in both allogeneic and autologous BMT is higher in the femoral neck than the lumbar vertebrae, occurring mainly in the first six months after BMT. Preventive and clinical procedures should be considered.
Eslamian L, Jamshidi A, Kaghaz Kanani R,
Volume 65, Issue 14 (3-2008)
Abstract
Background: Osteoporosis threatens the aged population especially the menopausal
women and can lead to life long disability and death. Appropriate knowledge and behavior
have an important role in prevention of osteoporosis. In this study the knowledge, attitude
and behavior of women regarding osteoporosis is assessed and compared in different age
groups.
Methods: This cross sectional study includes 390 women in reproductive, premenopausal
and menopausal age groups who had come to Shariati hospital clinics and each had
answered the designed questionnaire. The questionnaires were scored and analyzed.
Women’s knowledge, attitude and behavior were assessed and compared by X2 test in the
three age groups and P<0.05 was considered significant.
Results: 15–30% of women didn’t know what osteoporosis is and in 380 of them attitude or
behavior was not good. Education had a significant effect on knowledge of women in
reproductive and premenopausal ages (P=0.002, 0.04 respectively), but had no effect on
their attitude or behavior. Age had a significant effect on knowledge and attitude (P=0.001)
but had no effect on behavior. Age had significant effect on the knowledge that exercise
can prevent osteoporosis (P=0.014) but not on attitude or behavior. Age had no effect on
knowledge, attitude or behavior of daily calcium intake to prevent osteoporosis. (P=0.123,
0.12, 0.153 respectively) 93% to 95% of women thought the risks of osteoporosis are less
than cardiovascular disease or breast cancer.
Conclusions: 15–30% of women didn’t know what osteoporosis is. The total knowledge
about osteoporosis was low. Although 22-75% of women younger than 54 years old had
knowledge about the predisposing factors but their attitude or behavior was not good.
Larijani B, Alimadadi A,
Volume 68, Issue 9 (12-2010)
Abstract
Osteoporosis is a condition characterized with reduced bone density and destruction of the bone structure. The ideal treatment aims to reduce the risk of fracture while improving the density and structure of the bone. Parathormone (PTH) and its main analogue triparatide (rhPTH [1-34]) is a new class of anabolic medications which accelerates the healing process in the fractured bone through improving bone formation and therefore is used for treating severe osteoporosis. The present review article was designed to report the history, different types, anabolic and catabolic effects, complications, indications and contraindications of the hormone.
Aghaei M, Sedighi S, Behnam Pour N, Hezar Khani Sh, Jamshir M, Agh A, Shojaa M,
Volume 70, Issue 7 (10-2012)
Abstract
Background: Low bone mass is a serious health problem mostly seen in postmeno-pausal women with rheumatoid arthritis. The purpose of this study was to determine the prevalence of osteoporosis and some related risk factors in postmenopausal women with rheumatoid arthritis.
Methods: The data for this descriptive analytical study was extracted from the medical records of 98 postmenopausal women with rheumatoid arthritis who had attended the 5th of Azar Teaching Hospital affiliated to Gorgan University of Medical Sciences, in Iran, in 2009.
Results: The mean durations of menopause and rheumatoid arthritis were 9.39 and 5.13 years, respectively. The overall prevalence of osteoporosis was 13.3%. We found a significant correlation between age, disease duration, and duration of menopause with bone mineral density (P<0.05).
Conclusion: Our results indicate a high prevalence of osteoporosis at the lumbar spine of postmenopausal women with rheumatoid arthritis.
Ahmad Tahamoli Roudsari , Zahra Basiri , Farshid Mohammadi , Mohammadreza Baiat ,
Volume 76, Issue 8 (11-2018)
Abstract
Background: Osteoporosis is the most common metabolic disease of the bone in the world, and has hit about 200 million people around the world and it increases the risk of fractures. More than 5 million osteoporotic fractures occur annually in the world. Bone mineral density is the standard method of diagnosis of this disease. In this method, proximal of femur (neck) and lumbar vertebra bones (L2, L3, L4, L5) are typically evaluated. The aim of this study was determine the bone density profile of one third of distal radial bone in patients with primary osteoporosis.
Methods: This cross-sectional study conducted at Shahid Beheshi hospital in Hamadan city, from October 2015 to October 2016. Among of the patients, those over the age of 50 years old, 71 patients were selected by convenience sampling method taking into account if they have inclusion criteria (such as: age> 50 years, no systemic diseases, no history of corticosteroid use). For all patients that enter the study, lumbar, femoral neck and one third of distal radial bone densitometry was done by dual X-ray absorptiometry (DXA) method. Osteopenia and normal bone density the World Health Organization criteria were used to determine osteoporosis.
Results: In this research 71 people entered the study. The mean age of the patients was 62.25±9.36 (51-92) years. In term of gender 5.63% of patients were male and 94.37% female. Pearson correlation coefficient showed a positive and significant correlation between the results of one third of distal radius with neck and total femur bone and lumbar bones (P<0.05). Correlation between the T-score of one third of distal radius and total femoral neck was statistically significant (P<0.05). The mean age of patients was 62.25±9.36 years.
Conclusion: According to the findings of this study one third of distal radial bone mineral density has an acceptable sensitivity to detect osteoporosis. Radius bone density decreases much faster than lumbar, vertebra and femoral neck.
Seyed Mostafa Seyedmardani , Pooya Sedighiany, Yousef Roosta ,
Volume 80, Issue 5 (8-2022)
Abstract
Background: Non-traumatic bone fractures are considered a pathologic condition with various etiologies, including cancer metastases, osteoporosis, and long-term corticosteroid consumption, which can affect people's quality of life. The main aim of this study was to investigate the etiology of pathological bone fractures in patients who were referred to the Hospital.
Methods: In this cross-sectional study, all patients with non-traumatic pathological fractures were included from March 2015 to February 2019 at Imam Khomeini hospital in Urmia city. Data analysis was calculated by chi-square test using SPSS.ver.17.
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Results: A total of 168 patients participated in this study, of which 108 patients (64.3%) were female, and 60 patients (35.7%) were male with a mean age of 58.6±21.1 with a minimum and maximum age of 7 and 90 years old, respectively. According to the results, the most common etiologies consist of osteoporosis (33.3%), metastatic carcinoma (28.6%), and primary tumor (11.3%), respectively. Regarding the anatomical site involved, vertebrae (57.1%) and the neck of the proximal femur (27.4%) were detected as the most frequent sites with fractures, respectively. Moreover, a significant relationship was found between the fracture etiologies and demographics data (age and gender) (p<0.001). In this regard, osteoporosis and metastatic carcinoma were reported as the most common fracture etiologies in females and males. In addition, intertrochanteric-subtrochanteric (7.7%), distal femur (4.8%), intertrochanteric (1.2%), and acetabulum (1.2%) were considered other sites of fracture with less frequency. It is worth noting that for patients with ages less than fifty years old (<50 years old), commonly reported fracture etiology was the primary osteosarcoma, while in patients with ages more than fifty (>50 years old), osteoporosis was defined as the main fracture etiology.
Conclusion: Together, the present study results showed that osteoporosis and metastatic carcinoma were the most critical etiology of fractures, and there was a statistical correlation between demographic characteristics (such as gender and age) and pathological fracture etiologies. According to the statistical results, the most common sites exposed for fractures were also the vertebral and proximal femur.
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