Showing 5 results for Sinusitis
Naraghi M, Sazegar Aa,
Volume 60, Issue 2 (5-2002)
Abstract
Background: Endoscopic sinus surgery has been used for diagnosis and treatment of chronic inflammatory diseases of paranasal sinuses since recent years.
Materials and Methods: In this study 104 patients with chronic sinusitis (with or without polyps) which were managed with endoscopic sinus surgery (ESS) were followed for 6 to 24 months after surgery (24 patients refused to continue follow up) and the recovery rate of symptoms were evaluated.
Results: The effectiveness of this therapy is statistically approved and the most important symptom which diminished was nasal obstruction (from 95 percent to 18.5 percent), the least important symptom which diminished was anosmia (from 57 percent to 21 percent).
Conclusion: This study confirmed the efficacy of functional endoscopic sinus surgery in improvement of chronic sinusitis symptoms.
M. Hasibi, M. Mohraz, M. Haji Abdolbaghi, M. Rasouli Nejad, A. Bayat,
Volume 64, Issue 4 (7-2006)
Abstract
Background: Acute bacterial sinusitis is one of the most common causes for antibacterial treatment. Oral Penbactam (ampicillin- sulbactum or Sultamicillin) is a broad spectrum antibiotic and it has no significant side effect. To our knowledge, this is the first study in Iran in which, oral Penbactam has been prescribed for patients with acute bacterial sinusitis.
Methods: A randomized clinical trial was performed on 44 outpatients diagnosed with acute bacterial sinusitis in Amir- Aalam Hospital from March 2003-2004 to August 2004. Patients were randomized in 2 group: 23 to oral Penbactam (375 mg twice daily), and 21 to oral Co-amoxicolav (625 mg three times daily). Duration of treatment was 10 days for both groups.
Results: Both groups showed a significant clinical improvement after 10 days of treatment. In the Penbactam group, 19 of 23 (86.36%) and in the Co-amoxicolav group ,18 of 21 (85.71%) showed clinical improvement. In the Penbactam group, one patient (4.3 %) developed diarrhea and the medication was discontinued.
Conclusion: Oral Penbactam is an effective and safe antibiotic in the treatment of acute bacterial sinusitis and could be used as an alternative medication for acute bacterial sinusitis.
Ghanaati H, Aghaee S, Salehianzandi N, Shakiba M, Jalali S.a.h,
Volume 65, Issue 2 (3-2008)
Abstract
Background: Imaging abnormalities in the paranasal sinuses are regularly noted as incidental findings on MRI, however, little is known about their prevalence in the Iranian population. The purpose of this study was to classify these findings in the paranasal sinuses as seen on MRI and to investigate the prevalence, according to site and type of paranasal abnormality.
Methods: In this cross-sectional study, the T2-weighted axial MRI of 256 patients with diseases unrelated to their paranasal sinuses were reviewed between May 2002 and June 2003. The findings were categorized according to the anatomic location and the imaging characteristics of the abnormality. The abnormalities recorded included total sinus opacification, mucoperiosteal thickening >5mm, air fluid levels and retention cysts or polyps. Unilateral or bilateral involvement and septal deviation were also noted. A sinus was considered normal if it was fully aerated and no soft-tissue density was apparent within the cavity.
Results: Among our cases, 111 (43.5%) were male and 145 (56.5%) were female. Of these patients, abnormalities in one or more of the sinus groups were found in 110 subjects (42.9%), 55.5% of which were male and 44.5% were female (P=0.001). Maxillary sinus abnormalities were observed in 66.4% of the patients, while ethmoid sinus abnormalities were found in 63.6%. Of the ethmoid abnormalities, 21% were found in the anterior section, 9% in the middle ethmoid, and 8% in the posterior ethmoid. The most common abnormality found was mucosal thickening. Among our cases, 23.4% had septal deviation, which was significantly higher among those with sinusitis (29% versus 19.1% P<0.01).
Of those patients with sinus involvement, 16% were involved in the sphenoid sinus and 5% in the frontal sinus. The results obtained from the patients with sinus abnormality revealed that 85% suffered from cough, nasal obstruction, runny nose, facial pain and post nasal discharge and 24% had been diagnosed with chronic sinusitis by physician.
Conclusion: Our results showed that there was a high rate of incidental abnormalities in the paranasal sinuses that are unrelated to the patient's presenting problems.
Naghdi S, Anjeie F, Nakhostin Ansari N, Fathali M,
Volume 70, Issue 11 (2-2013)
Abstract
Background: The sino- nasal outcome test 20 (SNOT-20) is a self- report measure for the assessment of patients with rhinosinusitis. The aim of the present study was to translate the SNOT-20 into Persian, and to evaluate the reliability and validity of the Persian SNOT-20.
Methods: The SNOT-20 was translated from English into Persian. Thirty patients with chronic rhinosinusitis completed the Persian SNOT-20 two times with an interval of 1-2 weeks. Thirty healthy volunteers completed the Persian SNOT-20 for the evaluation of discriminant validity.
Results: Cronbach's alpha coefficient values were high with 0.88 for test and 0.90 for retest. ICC for test-retest reliability was 0.95. The scores of patients were significantly higher than those of the healthy subjects. There were no floor and ceiling effects.
Conclusion: The Persian SNOT-20 is a reliable and valid measure for the assessment of Persian speaking patients with rhinosinusitis.
Mohammad Farhadi, Mehdi Shekarabi, Shima Javadinia, Samileh Noorbaksh, Mahmood Faramarzi, Mohammad Reza Shokrollahi, Azardokht Tabatabaee,
Volume 71, Issue 8 (11-2013)
Abstract
Background: Nasal polyp (NP) is a benign mucosal mass located in both sinuses and nares which is mostly seen in association with cystic fibrosis, asthma or oversensitivity to aspirin. The prominent histological feature of NP is inflammatory cell infiltration with eosinophil predominance. Superantigens role in causing NP complications is already proven. Superantigens, which are mostly originated from Streptococci and Staphylococci, activate T cells strongly and increase the process of production and release of cytokines, and secretion of IgE from B cells, which in turn directly affects proinflammatory cells such as eosinophils, both in their tissues infiltration and functions.
Methods: The samples are collected from patients referring to ENT clinic in Rasoul Akram training Hospital in Tehran after thorough clinical and paraclinical examinations. For control group the samples collected from patients undergoing rhinoplasty. All the samples kept frozen and sent to immunology lab. The DNA of the excised tissues extracted and amplified by using the superantigens specific primers and PCR product detected by gel electrophoresis. The date analyzed by using mean and SD and χ2 analytical tools.
Results: Fifteen healthy individuals, 25 patients with rhinosinusitis and 24 with polyposis entered this trial. Group A Streptococcus toxin detection was significantly more frequent in those with nasal polyp and rhinosinusitis compared to healthy individuals (P=0.001 and 0.005, respectively), but the results were almost the same for those with nasal polyp and rhinosinusitis (P=0.4).
Conclusion: Streptococci may play an important role in induction or clinical exacerbation of polyposis and group A Streptococcus pyogenes exotoxin (SPEs) with superantigenic effects may have a crucial role in etiology and pathogenesis of polyps with or without rhinosinusitis. It is postulated that, T cells polyclonal activation by SPEs may cause recruitment of inflammatory cells in nasal mucosa. These inflammatory cells include IgE producing B cells laeding to allergic and inflammatory reactions in NP.
