Razmpa E, Sadeghi Hasanabadi. M, Asefi N, Arabi M,
Volume 65, Issue 2 (3-2008)
Abstract
Background: Thyroid cancer is a rare disease which includes less than 1%
percent of all human cancers. The aim of this study is to evaluate the
demographic characteristics and risk factors among patients with thyroid
malignancy at the Cancer institute and Imam Khomeini hospital in Tehran
Iran.
Methods: This is a retrospective descriptive study of the charts of 320
patients admitted with the diagnosis of thyroid malignancy based on
pathologic reports in the above- mentioned hospitals from 1992 to 2002.
Results: From the 320 patients diagnosed with thyroid malignancy 68.1%
were papillary cancer, 10.9% were follicular cancer, 10.6% were anaplastic
cancer, 9.06% were medullary cancer and 1.2% were lymphoma.
The average of the patients was 50.2 years, ranging from 12 to 98 years
60.6% were female and 39.4 %were male 22.8% of the patients had
histories of thyroid nodule and 5% had received radiation therapy.
From the anatomic point of view 57.5% of the cancers were in the right lobe
of thyroid, 38.1% were in left lobe and 4.4% in the isthmus. None of the
patients had positive family history of thyroid malignancy.
Conclusion:
Thyroid malignancy is more prevalent in the fifth decade of life and more
common among females. Therefore, among patients in this group, alarming
symptoms, such as anterior neck mass, thyroid nodule and voice change,
should be evaluated more seriously.
Soudeh Hamedi , Marzieh Hadavi , Farhad Mohammadi , Somayeh Behzadi, Kourosh Sayehmiri,
Volume 80, Issue 9 (12-2022)
Abstract
Background: As we know, thyroid nodules are common, but many of them are benign, and this shows that sampling of nodules is not necessary to diagnose benignity.The aim of this article was to determine the diagnostic accuracy of ultrasound features for diagnosing malignant thyroid nodules in patients referred to Fajr infirmary in Ilam.
Methods: This descriptive-cross-sectional study was conducted on 122 patients referred to Fajr Ilam Clinic in October 2015 to January 2018.Clinical characteristics such as age, gender, BMI and history of underlying thyroid diseases and Hashimoto's thyroiditis were collected with the help of a questionnaire.The dependence of ultrasound characteristics with thyroid malignancy was determined using a multivariate analysis test. This ultrasound feature was compared with the results of fine needle aspiration cytology and the diagnostic accuracy indices were calculated for each ultrasound feature.This article was conducted using statistical tests, chi-square, independent t-test, Mann-Whitney test, and bivariate logistic regression using Spss software.
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Results: The study sample included of 30(24.6%) malignant and 92(75.4%) benign nodules. Hypoechogenicity and microcalcification showed statistically significant positive associations with thyroid malignancy (P<0.05).Also, according to Fisher's exact test, 7% and 20% of men had benign and malignant nodules, and 86% and 80% of women had benign and malignant nodules, respectively. But there was no statistically significant difference between the two groups (P>0.05). Hypoechogenicity had 63.3% sensitivity and 67.04% specificity, microcalcification had 60% sensitivity and 65.93% specificity. Having at least one good sonographic feature resulted in the highest sensitivity (86.67%), while the presence of both features had almost perfect specificity (91.3%) and the highest positive likelihood ratio (4.21).
Conclusion: According to the results of this article, the presence of Microcalcification variables and Hypoechogenicity are the most important criteria in predicting thyroid malignancy, and they are Locate in the TI-RADS grading. Therefore, nodules larger than 1 cm in size with the characteristics of microcalcification and homogeneity ultrasound should be the main focus of diagnostic evaluations.
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