Volume 23, Issue 6 (1-2024)
ijdld 2024, 23(6): 398-408 |
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Bagheri L, Faramarzi M, Hemati farsani Z, Hossein zadeh M. Comparison of the Effect of a Course of Resistance and Endurance Training with Ursolic Acid Consumption on the Levels of Fetoin-A and B in the Liver Tissue of Elderly Male Diabetic Rats. ijdld 2024; 23 (6) :398-408
URL: http://ijdld.tums.ac.ir/article-1-6275-en.html
URL: http://ijdld.tums.ac.ir/article-1-6275-en.html
1- Department of Sport Sciences, Shahrekord University, Shahrekord, Iran
2- Faculty of Sport Sciences, Department of Exercise Physiology, University of Isfahan, Isfahan, Iran ,m.faramarzi@spr.ui.ac.ir
3- Department of Sport Sciences, Faculty of Humanities and Social, Ardakan University, Ardakan, Iran
4- Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Faculty of Sport Sciences, Department of Exercise Physiology, University of Isfahan, Isfahan, Iran ,
3- Department of Sport Sciences, Faculty of Humanities and Social, Ardakan University, Ardakan, Iran
4- Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract: (650 Views)
Background: Fetoin-A and -B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic acid consumption on the levels of Fetoin-A and -B in the liver tissue of elderly diabetics.
Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal.
Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group.
Conclusion: Considering the beneficial effects of exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics.
Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal.
Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group.
Conclusion: Considering the beneficial effects of exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics.
Type of Study: Research |
Subject:
Special
Received: 2023/08/8 | Accepted: 2023/10/31 | Published: 2024/01/30
Received: 2023/08/8 | Accepted: 2023/10/31 | Published: 2024/01/30
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