Volume 24, Issue 3 (7-2024)
ijdld 2024, 24(3): 162-169 |
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Yousefinejad M, Omidi M, Taheri kalani A. The Effect of 8 Weeks of Aerobic Training on Serum Levels of Asprosin and Insulin Resistance Index in Diabetic Rats. ijdld 2024; 24 (3) :162-169
URL: http://ijdld.tums.ac.ir/article-1-6298-en.html
URL: http://ijdld.tums.ac.ir/article-1-6298-en.html
1- Department of Sport Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran
2- Department of Sport Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran ,m2omidi@yahoo.com
2- Department of Sport Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran ,
Abstract: (526 Views)
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Keywords: Aerobic Exercise, Wistar Rat, Type 2 Diabetes Mellitus, Insulin Resistance, Asprosine Hormone
Type of Study: Research |
Subject:
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Received: 2023/10/13 | Accepted: 2024/01/10 | Published: 2024/07/31
Received: 2023/10/13 | Accepted: 2024/01/10 | Published: 2024/07/31
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