1- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
2- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran ,dr.sadeghi85@gmail.com
2- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran ,
Abstract: (55 Views)
Introduction: Understanding adipogenesis, the process of adipocyte development, may provide new insights to treat type II diabetes and related metabolic diseases. The present study investigates the effect of eight weeks of moderate-intensity continuous training and L-carnitine supplementation on Wnt10b protein expression related to visceral adipose tissue adipogenesis in streptozotocin (STZ)-induced diabetes in male rats.
Methods: In an experimental clinical-intervention study, 50 streptozotocin-induced 3 months diabetic rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). ). The training program consisted of three times a week for 30 minutes on a treadmill at a speed of 15 meters per minute. Five days a week, 30 mg/kg of L-Carnitine was given through drinking water. Expression of Wnt10b protein at visceral fat was measured by western blot method. Data analysis was performed with one-way analysis of variance and Tukey’s post hoc tests at a significant level (P<0.05).
Results: the results showed that the expression of Wnt10b protein, the Lipolysis inhibitory protein, in both (D+LC+T) groups and (D+T) decreased significantly (P<0.001).
Conclusion: According to the results, it seems that MICT exercise with L-carnitine supplement and alone is more effective in decreasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.
Methods: In an experimental clinical-intervention study, 50 streptozotocin-induced 3 months diabetic rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). ). The training program consisted of three times a week for 30 minutes on a treadmill at a speed of 15 meters per minute. Five days a week, 30 mg/kg of L-Carnitine was given through drinking water. Expression of Wnt10b protein at visceral fat was measured by western blot method. Data analysis was performed with one-way analysis of variance and Tukey’s post hoc tests at a significant level (P<0.05).
Results: the results showed that the expression of Wnt10b protein, the Lipolysis inhibitory protein, in both (D+LC+T) groups and (D+T) decreased significantly (P<0.001).
Conclusion: According to the results, it seems that MICT exercise with L-carnitine supplement and alone is more effective in decreasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.
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