slamic Azad University, Islamshahr Branch, Islamic Azad University , ma-nejadali@yahoo.com
Abstract: (80 Views)
Background: Type 2 Diabetes is a chronic metabolic disease characterized by by insulin resistance and inadequate insulin secretion by pancreatic beta cells. Insulin resistance is the most important characteristic of type 2 diabetes, in which the peripheral tissues, including the liver, skeletal muscles, and fat tissue, shows a lower response to the presence of insulin and insulin function is impaired. Adipose tissue, in addition to storing fat, synthesizes and secretes several bioactive peptides and molecules called adipokine and cytokine, which play an important role in regulating metabolism, inflammation, obesity and diabetes.
Methods: In the present study, Search in Persian and Latin databases PubMed, Science Direct, Google scholar SID, Magiran with the keywords Diabetes, Insulin Resistance, Adipokine, Adiponectin, Leptin, Resistin, TNF-α, IL-6 , RBP-4, Chemerin, Vaspin, Visfatin, Omentin, Aplin were performed to retrieve articles published from 2011 to 2024.
Results: The results show that adiponectin levels decrease in patients with type 2 diabetes and insulin resistance. Elevated levels of leptin and retinol-binding protein-4 play an important role in the development of insulin resistance and type 2 diabetes. Based on the evidence, adiponectin, resistin, TNF-α, interleukin-6, vaspin and visfatin are associated with insulin resistance and T2D. Contradictory results have been reported on the relationship of omentin, apelin and chemerin with insulin resistance and T2D.
Conclusion: Adipocytokines could be considered as a biomarker for predicting and early diagnosing insulin resistance and T2D.
Methods: In the present study, Search in Persian and Latin databases PubMed, Science Direct, Google scholar SID, Magiran with the keywords Diabetes, Insulin Resistance, Adipokine, Adiponectin, Leptin, Resistin, TNF-α, IL-6 , RBP-4, Chemerin, Vaspin, Visfatin, Omentin, Aplin were performed to retrieve articles published from 2011 to 2024.
Results: The results show that adiponectin levels decrease in patients with type 2 diabetes and insulin resistance. Elevated levels of leptin and retinol-binding protein-4 play an important role in the development of insulin resistance and type 2 diabetes. Based on the evidence, adiponectin, resistin, TNF-α, interleukin-6, vaspin and visfatin are associated with insulin resistance and T2D. Contradictory results have been reported on the relationship of omentin, apelin and chemerin with insulin resistance and T2D.
Conclusion: Adipocytokines could be considered as a biomarker for predicting and early diagnosing insulin resistance and T2D.
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