Iranian Journal of

Background and Objectives: The cancer of the pancreatic head and Ampulla of Vater is a malignant disease usually seen in advanced stages with symptoms caused by stomach and biliary obstruction. Curative treatment is possible in the early stage. Unfortunately, most symptomatic patients are in the advanced stage and have an unrespectable tumor; therefore, they should undergo palliative surgery. This study was performed to determine the complications and survival rate of patients who underwent palliative surgery for advanced stages of cancer in the Ampulla Vater and pancreatic head.

Methods: In this study, 49 patients with advanced stages of cancer in the Ampulla of Vater and pancreatic head who had undergone palliative surgery from 2003 to 2014 at Baqiyatallah Hospital were studied and the complications and survival rate were determined.

Results: Eleven patients (22.44%) underwent biliary bypass, 6 (12.24%) underwent gastric bypass, and 32 (65.32) underwent both procedures. Twelve (24.49%) patients developed complications. Anastomotic leak and peritonitis were the most common complications seen in 6 (12.2%). Seven patients (14.28%) died in the hospital. The mean survival was 5.47 ± 8.38 months. Upon follow up, survival was significantly longer in older patients (P=0.01).

Conclusion: In one-fourth of the patients with advanced stages of cancer, palliative surgery of the pancreatic head and Ampulla of Vater caused complications, and the mean survival rate was less than six months. The results of this study recommend the use of less invasive procedures such as biliary stenting in the advanced stages of the disease.