Volume 12, Issue 4 (Volume 12, No 4 2022)
jdc 2022, 12(4): 233-242 |
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Shomali K, Naeimifar A, Ahmadnasrollahi S. A review on the effects of urea in skin disorders. jdc 2022; 12 (4) :233-242
URL: http://jdc.tums.ac.ir/article-1-5562-en.html
URL: http://jdc.tums.ac.ir/article-1-5562-en.html
1- Jarf Andishan Navid Salamat (Janus) Corporation, Tehran, Iran
2- Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ,naimifar@gmail.com
3- Center for Research and Training in Skin Diseases and Leprosy,Tehran University of Medical Sciences, Tehran, Iran
2- Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ,
3- Center for Research and Training in Skin Diseases and Leprosy,Tehran University of Medical Sciences, Tehran, Iran
Abstract: (1521 Views)
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%),
urea-containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea-based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti-inflammatory and anti-fungal drugs, due to its activity as a penetration enhancer.
urea-containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea-based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti-inflammatory and anti-fungal drugs, due to its activity as a penetration enhancer.
Type of Study: Review |
Subject:
Special
Received: 2022/03/17 | Accepted: 2022/02/4 | Published: 2022/02/4
Received: 2022/03/17 | Accepted: 2022/02/4 | Published: 2022/02/4
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