Volume 29, Issue 2 (11-2016)                   jdm 2016, 29(2): 92-100 | Back to browse issues page

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Najafi S, Yazdani R, Salari B, Tehrani H F, Kharrazi Fard M J. Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study. jdm 2016; 29 (2) :92-100
URL: http://jdm.tums.ac.ir/article-1-5526-en.html
1- Assistant Professor, Department Oral Medicine, School of Dentistry, International Campus of Tehran University of Medical Sciences, Tehran
2- Assistant Professor, Department of Community Oral Health, School of Dentistry, International Campus of Tehran University of Medical Sciences, Tehran
3- Resident of Orthodontics, Department of Orthodontics, School of dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
4- Mycologist, Department of Microbiology, Shahid Beheshti University of Medical Sciences, Tehran
5- Statistical Consultant, Dental Research Center, School of Dentistry, International Campus of Tehran University of Medical Sciences, Tehran
Abstract:   (7074 Views)

Background and Aims: The aim of this study was to investigate the effects of sodium bicarbonate against candida albicans, the main infectious factor of denture stomatitis, and to compare it with other common anti-candida medications.

Materials and Methods: Three concentrations of Candida albicans (105, 106, 107 CFU/mL) were prepared. Experimental substances were 5% sodium bicarbonate, nystatin, chlorhexidine, and sterile saline (as control). Each of them was added separately to the same amounts of Candida albicans of different concentrations, and sampled at the intervals of 1, 2, 3 and 4 min. Then, the samples were cultured and incubated. The number of formed colonies was counted for each plate. The data were analyzed, using ANOVA and Tukey test.

Results: Sodium bicarbonate showed a noticeable anti-candida effect on the concentrations of 105 and 106 CFU/mL, with almost similar anti-candida effect as nystatin and chlorehexidine(P=0.29, P=0.32). Nystatin was the most effective medication on the concentration of 107 CFU/mL of candida (P=0.03, P=0.01). Sodium bicarbonate and chlorhexidine were less effective in this concentration with no statistically significant difference (P=1.00).

Conclusion: Sodium bicarbonate showed a significant anti-candida effect at low and medium concentrations of Candida albicans, but nystatin was more effective in the higher concentrations.

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Type of Study: Research | Subject: general
Received: 2016/11/7 | Accepted: 2016/11/7 | Published: 2016/11/7

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