Background and aim: There is neuroplasticity in all of life time, from newborn to elderly and neuronal connections are being created and broken by experiences and states of health or disease. The recovery of people with stroke or cerebral palsy can be a sign of neuroplasticity.

The aim of this article is to detect significance of neuroplasticity and critical period of recovery in central nervous system after stroke and cerebral palsy.

Materials and methods: This study is based on review of internal and external articles that published about neuroplasticity in central nervous system after stroke and cerebral palsy from 1987 to 2007.

Results: According to review the articles the mechanisms of neuroplasticity after stroke and cerebral palsy consist of Axonal and dendrites Sprouting, cortical reorganization and neurogenesis.

The rehabilitation protocols have a direct effect on integration and reorganization in intact areas adjacent to injured motor areas of cortex.

Conclusion: This study showed that reorganization continually occurs in response to task, behavior and learning skills.