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E Kazemi, S Talari, H Hooshyar,
Volume 5, Issue 3 (4 2007)
Abstract
Background and aim: Cutaneous leishmaniasis (CL) is endemic in Iran and many other countries. The use of pentavalent antimony compounds for the treatment of this disease is associated with serious side effects. There have been reports of the effect of the extract of Berberis vulgaris root on leishmania major, both in vitro and in vivo. The goal of the present study was to investigate the effect of an alcoholic extract of this plant on experimental L. major ulcers in BALB/c mice. The experiment was conducted in 2006 by the Department of Parasitology, Kashan University of Medical sciences.
Materials and Methods: We used different concentrations of an alcoholic extract of Berberis vulgaris in the form of an ointment. Ninety BALB/c mice received a subcutaneous inoculation of 0.1 ml liquid-phase culture of infective L. major (MRHO/IR/75/ER standard variety) in the base of their tail. Ulcers appeared after 30-35 days and these were divided into 5 groups: 3 groups received treatment with 20%, 40%, and 80% concentrations and the remaining 2 groups served as controls. The extract was used applied topically, three times a day for 30 days. Each weak we measured the diameter of the lesions and the animals' weight. After preparation and staining, we determined the number of parasites in lesions through microscopic examinations. Results were recorded on paper and analyzed with the use of Student's t and Fisher's exact tests as well as analysis of variance and Tokey's post-hoc tests.
Results: With the 20% preparation: By the end of the treatment period, the mean diameter of the lesions had decreased, with complete healing in 5 mice (27.7%), (p< 0.001). By the time of the decrease in diameter, the mean weight of the animals had increased and the number of parasites in the lesions had declined (80%). Total elimination of the parasites was observed in 12 animals (p<0.001).
At a concentration of 40%: Mean ulcer diameter decreased, with complete healing in 2 mice (11.1%, p<0.001). By the time of the decrease in diameter, the mean weight of the mice had increased (p<0.05). The mean number of parasites in lesions decreased (64.3%), with total elimination in 9 animals (p< 0.05).
Conclusion: We showed that the extract of Berberis vulgaris is most effective at a concentration of 20%, causing greater reductions in both ulcer diameter and the number of parasites in the lesions compared to other preparations. Therefore, we suggest the use of a 20% extract for the treatment of human cases.
Hashem Mohammadian, Gholamabbas Moosavi, Hasan Eftekhar Ardebili,
Volume 11, Issue 4 (3-2014)
Abstract
Background and Aim: This study aimed gender variations about adolescents' health-related quality of life.
Materials and Methods: A cross-sectional study was performed on four hundred students selected by a Stratified random sampling. Two-way analysis of variance was used for the analysis of total health-related quality of life scores among boys and girls in terms of demographic factors. Data analysis was conducted with software SPSS 18 and LISREL8.8 programs.
Results: There were important differences in health-related quality of life total score between boys and girls in relevance rank of birth, level of education and BMI. Although, these differences weren't statistically significant (p>0.05), Girls’ reports were higher compared to boys except for the emotional functioning subscale.
Conclusions: Teachers and parents should make great efforts for meet the requirements and difficulties of emotional and behavioral in adolescent girls. It is Necessary to execute coping mechanisms by the training consultants to minimize stress and anxiety for the mother to be.
Mansour Halimi, Manouchehr Farajzadeh, Mehdi Delavari, Hadi Bagheri,
Volume 12, Issue 1 (5-2014)
Abstract
Background and Aim: Environmental and ecological factors especially climatic conditions have a significant impact on the prevalence of parasitic diseases. These factors has is more importance in Malaria Incidence and Epidemiology. Malaria as the most important parasitic disease, considered as one of most important public health problem. The climatic factors not only affect the growth and proliferation of the Anopheles mosquito but also affect in Plasmodium activity . In present study we surveyed the malaria situation during 1972 to 2005. In order to the five climatic parameters including mean temperature, total precipitation, number of days with precipitation over 0mm, rainfall distribution index and relative humidity were used as annual average during 1971 to 2005.
Materials and Methods : we calculate average of annual of climatic parameters for the 31 synoptic stations of Iran Using GIS software. First, using the ordinary Kriging model with spherical a Semi variogram was traced maps of climatic parameters and these factors mean was calculated for each year . Finally, to investigate the relationship between climatic parameters with the prevalence index the Pearson correlation coefficient at 0.9 confidence level (p = 0.10) . was used. A multivariate linear regression model was applied to estimate the prevalence of disease based on the mentioned climatic factors .
Results : Study of malaria prevalence in 1971 to 2005 showed cases of disease with has a decreasing trend with slope 0.0142 in year that this trend has been accelerated from 1375 . Many cases of disease have been reported one year after increased precipitation . The result showed the weather humidity factors is important than temperature factors in the prevalence of malaria . I general, the developed model is explained 0.48 of changes prevalence time.
Conclusion: In order to be successful Anti-malaria campaign in Malaria-prone areas in addition different influencing factors climatic factors should be considered .
Hashem Mohammadian, Seyed Gholam Abbas Mousavi, Hasan Eftekhar Ardebili, Jafar Kord Zanganeh,
Volume 12, Issue 4 (3-2015)
Abstract
Background and Aim: It is known that personal behavior influences one’s health. The present study was designed to investigate lifestyle of non-medical students of governmental and private (Azad) universities in Kashan, Iran and factors affecting it.
Materials and Methods: A cross-sectional study was carried out on 520 non-medical students in Kashan, Iran, selected by convenience sampling, in academic year 2013-14. Data on demographic characteristics and health behaviors were collected using standard valid questionnaires, for the latter the questionnaire being the Pender’s Health Promoting Lifestyle Profile II (HPLP II). The data were analyzed using the Kolmogorov-Smirnov test, followed by t-test, and U Mann-Whitney test to compare the means of the two populations.
Results: The m ean age of the students was 21.75 ± 2.5 years. Their overall health-promoting lifestyle score was of 2.43 (SD = 0.38). This score, as well as scores for the subcategories ─ nutritional behavior, spiritual development, physical activity, health responsibility, and stress management ─ were lower for the subjects with an experience of stressful events. Further analysis of the data showed that t here were significant differences between boys and girls as regards physical activity (P = 0.000), between single and married students as regards nutritional status (P = 0.032), and between working and non-working students as regards spiritual development (P = 0.014).
Conclusion: The findings indicate that experienced stressful events lay the ground for the adoption of risky behaviors in university students. Therefore, universities should design and implement programs aiming at improving lifestyle of the students and promoting their health.
Zahra Karimian, Fatemeh Atoof, Razieh Maasoumi, Mohammad Ali Besharat, Effat Sadat Merghati Khoei,
Volume 15, Issue 2 (9-2017)
Abstract
Background and Aim: Considering that the knowledge of, and attitude towards, sexuality is a key factor influencing sexual behavior, the main objective of this survey was to determine the bases of sexual knowledge and formation of attitude towards sexual script in women of reproductive age in Kashan City, Iran.
Materials and Methods: This was a cross-sectional study including 500 women of reproductive age referring to all health centers in Kashan Iran, selected by simple random sampling,. The data collection tool was the Sexual Knowledge and Attitude Scale (SKAS). The data were analyzed using descriptive statistics, correlation and regression model.
Results: The age range of the majority of the participants (51.9%) was 26-35 years, and the educational level of 39.9 % of them was high school education. The majority of them had a high level of sexual knowledge and attitude (51.4% and 62.9% respectively). The Pearson correlation test showed a significant positive correlation between knowledge and attitude of the women (p<0.05), and based on the multivariate regression analysis their knowledge score correlated with education and economic status and their sexual attitude scores with age and education.
Conclusion: The participating women were young and educated and their knowledge and attitude scores were high. However, they had erroneous attitudes and ideas, such as a feeling of shame and anxiety at intercourse, considering initiation in sexual relation responsibility of the man, and considering childbearing as the main purpose in sexual relations. It is essential to design and implement appropriate educational programs to help the women change their attitudes and ideas.
Ahmad Ali Noorbala, Hossein Malek Afzali, Nasrin Abedinia, Marzieh Akhbari, Alireza Moravveji, Fatemeh Vaseghi, Zahra Nakhi, Mamak Shariat, Maryam Mirzaeeneyestani, Fatemeh Sadat Ghoreishi,
Volume 16, Issue 3 (12-2018)
Abstract
Background and Aim: Stress during pregnancy can have a lasting effect on the mental health of women after childbirth. Statistics show that about 18% of pregnant women have major or partial depression during pregnancy, but many have not been screened or treated. Lack of treatment can have serious consequences for the mother and her child. The purpose of this study was to determine the mental health status and marital satisfaction of pregnant mothers in Kashan city, Iran in 2015.
Materials and Methods: This was an analytical cross-sectional study. Using the convenience sampling method 202 pregnant women were selected from four urban health centers in Kashan, Iran and entered the study. Data were collected using a Diagnostic Interview, the General Health-28 Questionnaire and the Golombok Rust Inventory of Marital State. Descriptive statistics was used for data analysis, the statistical tests being one-way ANOVA, chi-square test, Pearson correlation test and logistic regression.
Results: The results showed that 26.7% of the pregnant women were suffering from psychiatric disorders, the most and least serious disorders being related to physical activity and depression, respectively. About 80% of the women expressed very good marital satisfaction. Further analysis of the data showed statistically significant associations between depression and age and anxiety, insomnia and duration of marriage, marital satisfaction and delivery type, and mental health and marital satisfaction. Furthermore, marital satisfaction had a negative association with education. (p<0.05).
Conclusion: It seems that it is essential to develop and implement a therapeutic, psychiatric and health care model for women at risk of psychiatric disorders during pregnancy and after childbirth in the health service delivery system in Iran.
