Showing 8 results for Alizadeh
Z Zarei Ghane, A Mirshafiey, A.r Razavi, A Sarafnejad, N Aalizadeh, M.r Khorramizadeh,
Volume 8, Issue 2 (21 2010)
Abstract
Background and Aim: Multiple sclerosis (MS) is considered as a common inflammatory disease of the human central nervous system (CNS). 4 amino pyridine (4-AP), a potassium channel blocker, is used widely in MS treatment to reduce fatigue and cachexia often experienced by the patients. The objective of this study was to get a better understanding of the mechanism of action of this drug, using the cell culture model. More specifically, we attempted to determine the effects of the drug on 1. The profileration of, and its cytotoxicity on, the neurons, and 2. The activity of MMP-9 in the neurons.
Materials and Methods: Considering the available reports on the wide range of 4-AP effects, we designed this study to investigate its possible role in proliferation or cytotoxicity of the MS cellular model, i.e. astrocytoma U373-MG, using the MTT assay technique. We also analyzed the effect of 4-AP on cell functionality as assessed by matrix metalloproteinase-9 (MMP-9) zymography.
Results: The results showed that while 4-AP at a concentration of 0.1 and 1 mM has no significant cytotoxic effects on the treated cells, it has remarkable MMP-9 inhibitory effects (p<0.01). The proliferation analyses confirmed the stability of 4-AP effects on cell functionality.
Conclusion: On the whole, the results of the present study show the desirable effect of 4-AP on MMP-9 activity at non-cytotoxic doses, promising its further therapeutic applications.
Alireza Didarloo, Davood Shojaeizadeh, Hasan Eftekhar Ardebili, Shamseddin Niknami, Ebrahim Hajizadeh, Mohammad Alizadeh,
Volume 9, Issue 2 (21 2011)
Abstract
Background and Aim: Many studies show that the only way to control diabetes and prevent its debilitating complications is continuous self-care. This study aimed to determine factors affecting self-care behavior of diabetic women in Khoy City, Iran based the extended theory of reasoned action (ETRA).
Materials and Methods: A sample of 352 women with type 2 diabetes referring to a Diabetes Clinic in Khoy City in West Azarbaijan Province, Iran participated in the study. Appropriate instruments were designed to measure the relevant variables (diabetes knowledge, personal beliefs, subjective norm, self-efficacy and behavioral intention, and self-care behavior) based on ETRA. Reliability and validity of the instruments were determined prior to the study. Statistical analysis of the data was done using the SPSS-version 16 software.
Results: Based on the data obtained, the proposed model could predict and explain 41% and 26.2% of the variance of behavioral intention and self-care, respectively, in women with type-2 diabetes. The data also indicated that among the constructs of the model perceived self-efficacy was the strongest predictor for intention for self-care behavior. This construct affected both directly and indirectly self-care behavior. The next strongest predictors were attitudes, social pressures, social norms, and intervals between visiting patients by the treating team.
Conclusion: The proposed model can predict self-care behavior very well. Thus, it may form the basis for educational interventions aiming at promoting self-care and, ultimately, controlling diabetes.
Marzieh Farnia, Mohammad Shahbazi, Ghobad Moradi, Sepideh Alizadeh, Bahman Ebrahi, Maryam Kandi Kalle,
Volume 11, Issue 1 (8-2013)
Abstract
Background and Aim: probably after pestilence, HIV/AIDS is most important and severe health threat for public health. Prisons could facilitate the spread of HIV/AIDS and Hepatitis and transmit it to societies. The main strategy to control HIV/AIDS and hepatitis among Injecting Drug Users is Harm Reduction Programs. These programs are conducted in Iran Prisons. The goal of this study is to evaluate Harm reduction Programs including Methadone Maintenance Therapy (MMT) and Needle exchange from the viewpoint of prison staff in Iran including principals, managers, physicians and counselors.
Materials and Methods : It was a cross sectional study in which 370 prison staff working in prisons all around the country were evaluated to assess their viewpoint and insight about Harm reduction Programs including Methadone Maintenance therapy and Needle exchange.
Results: A percentage of 95.23 of prison managers and experts had a positive view toward Methadone Maintenance therapy. 70.25 percent had a positive insight toward needle exchange program. The employment type and work experience was significantly (p<0.05) related to the viewpoint of managers and experts towards Methadone Maintenance therapy program. Age was the only factor that had a significant relationship (p<0.05) with Needle exchange program.
Conclusion: MMT has lots of supporters in prisons. The positive insights of managers and experts towards methadone maintenance therapy program demonstrate the high level of staff’s approval for conducting this program it could be interpreted as a sign of success of program in the country. However there is not a comprehensive approval and collaboration with needle exchange program in prisons. Nevertheless, it is alarming that 42.5% of staff believe that conducting methadone maintenance therapy may increase and intensify addiction in prisons.
Shahnaz Rimaz, Effat Merghati Khoii, Fatemeh Zareie, Neda Shamsalizadeh,
Volume 11, Issue 1 (8-2013)
Abstract
Background and Aim: Women perceive menopause differently. Beside biological changes, women experience menopause based on the cultural scenarios. The qualitative research presented here is about how Iranian women perceive menopause within cultural scenarios.
Materials and Methods : Data was collected during 4 focus group sessions and 6 individual in-depth interviews of women aged 40 years and older. Informants were selected from the Tehran University of Medical Sciences. The sessions were facilitated by using a semi-structured inventory focus group. Content analysis was adopted using combined free and analytical coding to reduce data, to extract meanings, to categorize domains and to obtain themes .
Results: We categorized our findings into four main domains: gender role, the changes in socialization, social interactions and supporting resources. Descriptions of the later domain are going to be reported in subsequent manuscript.
Conclusion: The women's understandings of menopause are shaped based on the specific cultural scenarios. Menopause recognized as a factor which changes women’s life line. Meanings as 'Loosing femininity' and 'changes in women's roles in the community' describe women's gender role, social interactions and changes in the socialization throughout the menopause years. The women’s misconceptions, accumulated myths, and ignorance about femininity were evidenced based on narratives. The majority of women raised ‘role change’ as an important determinant in social interactions. Gender role changes as well as women's socialization patterns have forced women to accept loosing femininity as a reality. Developing comprehensive and culturally sensitive health services to address women's needs in the climacteric years is suggested .
Effat Merghati-Khoei, Neda Shams Alizadeh, Alireza Bayat, Fatemeh Zarei, Shahnaz Rimaz,
Volume 12, Issue 2 (10-2014)
Abstract
Background and Aim: Health-risk behaviors are socially constructed and influenced by the given culture. Therefore, the health-risk behaviors are prioritized differently in diverse cultures. In this study, we aimed to explore the priority of health risk behaviors among high school students in Tehran.
Materials and Methods : In this qualitative study using rapid assessment approach, we interviewed 130 individuals who voluntarily participated in the focus group discussions (FGDs, n=17). They were students (n=9 FGDs), the parents (n=5 FGDs), and the teachers (n=3 FGDs). Four of the principals were individually interviewed. Interviews focused on (1) perceptions about and description of healthy or unhealthy behaviors (2) priority of health risk behaviors in adolescents (3) perceptions and beliefs about the formation of the risk behaviors among adolescents. All sessions were embarked on the public schools located in the area five in West Tehran. After obtaining a written consent form from the participants, primary investigators and three of the trained facilitators (male and female) conducted the sessions. We employed content analysis to extract the major themes and sub-themes. The rigor of the data was obtained.
Results : Addiction, risky sexual behavior, and social misconduct ion (aggression) were identified as the main concerns for the boys. Risky sexual behavior, early marriage, eating unhealthy habits, physical motionless, and fear of the future (job, education, marriage) were identified as the main health-risk behaviors for the girls.
Conclusion : According to our findings, health risk behaviors are classified differently for boys and girls. However, sexual risk behaviors are common findings for both groups. The adolescents' risky behaviors are formed throughout their socialization and seriously influenced by the given culture. Understanding of gender schema was identified as an important factor in the way participants do priority health-risk behaviors of young people. Comprehensive and holistic health education and promotion programs targeting adolescents as well as training programs for parents are suggested.
Monireh Khadem, Seyed Jamaleddin Shahtaheri, Farideh Golbabaei, Abbas Rahimi Foroushani, Mohammad Reza Ganj Alizadeh, Farnoush Faridbod,
Volume 12, Issue 4 (3-2015)
Abstract
Background and Aim: The aim of this study was to assess exposure of workers in a metal industry to nickel and lead.
Materials and Methods: Extraction was done using the solid-phase extraction on Chromosorb-102 resin to prepare, concentrate and purify biological samples of urine, hair and nails of workers working in metal industries. The variables influencing response (pH, loading flow rate, elution solvent, and amount of resins, elution volume, and sample volume) were examined and the procedure was optimized. The optimized procedure was, then, validated based on the “within-day” and “day-to-day” reproducibility experiments, using low, medium and high concentrations, leading to a satisfactory accuracy and precision. Finally, lead and nickel samples were taken from the workers and their concentrations determined voltammetrically.
Results: The optimum values for the examined parameters were as follows: pH = 9, ligand concentration = 0.05%, loading flow rate = 5 ml/min, elution solvent = 2M HNO3, amount of resins = 500 mg, elution volume = 15 ml, and sample volume up to 500 ml. A good reproducibility and repeatability was obtained for the optimized method under the existing conditions. Lead and nickel could be extracted with recoveries in the range of 94-100%. On the whole, the concentrations of nickel and lead in the workers’ biological samples were above the respective maximum permitted levels.
Conclusion: Solid-phase extraction procedure is a fast and simple method for preconcentrating and isolating analytes from biological samples. Considering the low concentrations of the analytes and presence of confounding factors in such samples, the procedure can be very effective for their preparation. The application of the developed method indicates that trace metal ions can be effectively purified and preconcentrated from different matrices like urine, hair and nail samples to assess occupational exposures.
Farzaneh Valizadeh, Aziz Allah Batebi, Abolghasem Pourreza, Azadeh Deylami,
Volume 14, Issue 2 (9-2016)
Abstract
Background and Aim: Thalassemia major (ThM) is one of the most common autosomal recessive genetic disorders in the world. Its prevention and control is a priority in the disease prevention programs in the Iranian health system. The ThM screening program (screening at the time of marriage) has been an important step in its prevention in Iran. This study aimed to evaluate this program.
Materials and Methods: This was a descriptive-analytical study in Babosar District consisting of two phases. The first phase was a retrospective descriptive study aiming at finding the background causes of the diseases in subjects under 18 years old (born after March 1997). In phase 2, then, in an interventional analytical study, screening was repeated along with laboratory tests before, or at the beginning of, pregnancy (n = 5500).
Results: Phase 1(cross-sectional descriptive): There were 25 cases of ThM under 18 years old, parents of 15 of whom (60%) had married before 1997 and 4 (16%) had children suffering from ThM (S2). The parents of the remaining 10 (40%) had married after 1997 (S1). Phase 2: Considering the findings of Phase1, an interventional program called thalassemia screening was started in September 2006 including 9750 pregnant or pre-pregnanct mothers. The program led to identifying 20 new beta-thalassemia-carrier couples, including 10 couples married before 1997 and 10 married after 1997 (without official marriage registration, laboratory errors and hemoglobinopathies). All the 20 couples were quickly referred to the Genetic Center, which resulted in prevention of the birth of 4 ThM neonates.
Conclusion: The 9-year intervention (2006-2015) resulted in timely action, preventing birth of 4 thalassemia major babies. Considering incidence of the disease during the previous 9 years (1997-2006), it can be concluded that the before-after randomized clinical trial is an effective way to reduce thalassemia major incidence.
Farzaneh Valizadeh, Afsaneh Keramat,
Volume 17, Issue 2 (9-2019)
Abstract
Background and Aim: Happiness and benevolence in individual life and satisfaction in marital life are very important from a social point of view. Happiness is one of the most important factors for strengthening and sustainability of marital relationships.
Materials and Methods: A thorough search was done in the following data banks using the Persian and English key words happiness, marital satisfaction and Iran: Magiran, Pubmed, Web of Science, IranDoc, IranMedex and SID. In the initial search, 41 articles were found and studied. After reviewing the full texts of the articles, 8 papers were finally selected for analysis. Data were analyzed using the Revman software, the statistical test being meta-analysis (random effects model).
Results: In the 8 articles (published during the period 2006-2018) which were analyzed, the total number of study participants was 1563. The means of the completed Oxford happiness and Enrich's marital satisfaction questionnaires were 57.3 and 137.2, respectively
Conclusion: Based on the findings, it is concluded that there is a positive correlation between happiness and marital satisfaction of couples in Iran.Therefore, implementing appropriate educational and public health programs is necessary to strengthen the underlying factors of hope and happiness in order to increase the life satisfaction of couples and reduce family conflicts and divorces.
