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Showing 4 results for Derakhshan

A Ardalan , K Holakouie Naieni , M Mahmoudi , R Majdzadeh , P Derakhshandeh Peykar ,
Volume 4, Issue 2 (3 2006)
Abstract

Background and Aim: Limitations of the traditional methods for assessing G*E interaction- including case-control studies- led to development of several non-traditional approaches. This study aims to assess the interaction between the genetic background (history of breast cancer in first degree relatives) and environmental influences (reproductive/menstrual factors) in patients with breast cancer we also compare the statistical efficiency and power of case-control and case-only designs in this setting.
Materials and Methods: In a matched case-control study in Mazandaran province (Iran), 250 incident biopsy-proven cases of breast cancer and 250 age-matched neighbor controls were interviewed. History of breast cancer in mother and/or sister(s) was taken as a surrogate measure of genetic predisposition, while age at first birth, parity, breast feeding, age at menarche and irregular menstruation were considered as relevant environmental factors. For the matched case-control design, we used a conditional logistic regression model to examine main effects and the G*E interaction. In the case-only design, logistic regression analysis was applied to obtain an estimate of G*E interaction, after checking for the independence assumption. We also calculated the power for detecting the interaction by matched case-control and case-only analyses.
Results: Age at first delivery did not meet the assumption of independence (p=0.02), and so was not included in the case-only analysis. No statistically significant interaction effect was seen in the case-control analysis, while case-only analysis showed significant negative interaction between disease in first-degree relatives on the one hand and parity and breast feeding on the other. We also detected a significant positive interaction between genetic predisposition and age at menarche. All the estimated 95% confidence intervals for OR in G*E interactions were narrower in the case-only analysis. For all factors, the power for detecting G*E interaction was greater in the case-only analysis compared to the case-control analysis, with ratios ranging from 1.08 to 2.23.
Conclusion: The case-only design is more efficient and powerful than the case-control design for detecting gene-environment interaction under the assumption of independence. Baseline disease risk, interactions and independent effects should be considered in using the control data for checking the assumption of independence. Considering the existence of another explanatory variable, eg. a mutant gene which may have passed unnoticed, would be the safest approach in a case-only study.
R Ebrahimzadeh Vesal, E Shahgholi, P Derakhshandeh-Peykar,
Volume 7, Issue 2 (4 2009)
Abstract

Background and Aim: Thalassemia is one of the most common worldwide single-gene diseases. On the molecular level, it is a heterogeneous disease. So far, beside large deletions, more than fifty point mutations have been identified for this disease around the world. Four to ten percent of Iranians are carriers of thalassemia-affected genes. In this study we determined the relationship between the value of MCV/MCH and the type and severity of mutations in alpha thalassemia carriers.

Methods and Materials: The major abnormality in alpha thalassemia carriers is decreased values of MCV and MCH. A total of 104 adult alpha thalassemia heterozygotes, 20-40 years old, including 33 persons from Khoozestan Province and 71 from Khorasan Province, were included in the study. Two hundred and eight chromosomes were isolated from peripheral blood leukocytes using standard procedures. DNA samples were amplified by Gap-PCR.

Results: Only one ° mutation (MED) was found in 2.9% of the population. The carriers of this mutation had virtually identical ranges of MCV and MCH. In contrast, + mutations were associated with significant differences in mean MCV and MCH values. The various mean MCV/MCH ratios of ° carriers were statistically significantly lower than those of + heterozygote. The results indicated that the degree of reduction in MCV and MCH is directly related to the severity of the mutations. Deviations, in cases, were associated with lower numbers of the carriers.

Conclusion: Only one ° mutation (MED) was found in 2.9% of the population. The carriers of this mutation had virtually identical ranges of MCV and MCH. In contrast, + mutations were associated with significant differences in mean MCV and MCH values. The various mean MCV/MCH ratios of ° carriers were statistically significantly lower than those of + heterozygote. The results indicated that the degree of reduction in MCV and MCH is directly related to the severity of the mutations. Deviations, in cases, were associated with lower numbers of the carriers.


M Behfar, M.a Ehsani, P Salamati, K Holakouie Naieni, R Jamshidi, P Derakhshandeh-Peykar,
Volume 8, Issue 4 (20 2011)
Abstract

Background and Aim: Thalassemia, a heterogeneous disease, is one of the most common single-gene diseases worldwide. The aim of this study was to find associations between hematological indices and severity of beta-globin gene mutations in beta-thalassemia carriers.
Materials and Methods: In this cross-sectional study, 30 beta-goblin gene mutations (b+ and b○) in 1206 unrelated beta-thalassemia carriers were investigated. In addition, their hematological indices, including CBC and electrophoresis results, were determined. The association between genetic findings and hematological parameters (mean corpuscular volume (MCV) and mean hematocrit corpuscular hematocrit (MCH)) were determined using the SPSS software, the statistical test being the t-test.
Results: The results indicated that b+-thalassemia carriers had higher MCV and MCH means than b○-thalassemia carriers. These findings would certainly have practical implications in public health.
Conclusion: The results show a significant correlation between two hematological indices and certain types of mutations in beta-thalassemia carriers.
Arezoo Fallahi, Siamak Derakhshan, Tahereh Pashaee, Parvaneh Teymoori,
Volume 13, Issue 2 (9-2015)
Abstract

  Background and Aim: Although self-care is known to affect favorably the control and treatment of osteoporosis, the effective factors from the patients’ viewpoint have not been investigated. The aim of this study was to explore factors affecting self-care from the viewpoint of women suffering from osteoporosis.

  Materials and methods: This was a qualitative study conducted with a content analysis approach in 2014, including 15 women consulting the bone mass densitometry centers in Sanandaj, Iran, selected by purposeful sampling. The inclusion criteria were women aged &ge 50 years suffering from osteoporosis diagnosed definitively at least 6 months before, a T-score index > -2.5 (lower back or hip bone), taking drugs upon a physicians advice, ability to speak, and willingness to participate in the study. Data were collected through face-to-face and group semi-structured in-depth interviews and analyzed using the content analysis method. The accuracy and rigor of the data were confirmed based on such criteria as credibility, confirmability and transferability.

  Results: Five main categories were extracted including “ background factors of the disease ”, “hope and weakness in confrontation with the disease”, “role of the physician”, “role of the family”, and “administrative centers and organizations”. Based on further analysis of the data, 11 subcategories were emerged including “cultural issues”, “lack of knowledge”, “non-priority of health”, “weakness and fear”,

  “hope for the future” , “positive role of the physician”, “negative role of the physician”, “ active role of the family”, “ passive role of the family”, “ role of the media”, and “information centers”.

  Conclusion: The finding of the study show that the responsibility of women suffering from osteoporosis towards their health is not a single-factor, but rather a multifactorial, phenomenon. Pre-requisites for empowering women to adopt self-care behaviors include increasing their hope to live longer, physician’s attention to the patient’s needs, increasing health promotion programs in the media, and strengthening role of the family (particularly role of men).



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