Showing 4 results for Honarvar
Mohammad Hassan Eftekhari, Niaz Mohammadzadeh Honarvar, Abdolreza Rajaiefard, Ali Akbar Owji,
Volume 9, Issue 4 (13 2012)
Abstract
Background and Aim: It is known that oxidative stress plays an important role in the pathogenesis of diabetes. Consequently, use of antioxidant for treating and preventing complications of this disease is believed to be beneficial. Considering the antioxidant effects of soy isoflavones, this study was initiated to determine the effects of genistein, one of the isoflavones in soybeans, on serum glucose, lipid profile, and paraoxonase activity in diabetic rats.
Materials and Methods: Thirty-six male Sprague Dawley rats were divided randomly into three groups, in 2 of which diabetes was induced by intravenous injection of 60 mg/kg body weight stereptozotocine dissolved in a 0.05 mol/liter citrate buffer the criterion for diabetes was a plasma glucose level above 250 mg/dl. All the 3 groups were fed a standard diet for 3 weeks, genistein (95% purity) being added to the diet of one of the diabetic groups at a level of 600 mg/kg diet. Fasting blood samples from the tail were taken at baseline and at the end of the period for measuring glucose, lipids, and paraxonase activity. The statistical test used for data analysis and inter-group comparisons was ANOVA.
Results: Supplementation with genistein had no statistically significant effects on the serum paraxonase activity or glucose level, but it brought about significant decreases in the serum triglyceride and total, HDL- and LDL-cholesterol levels.
Conclusion: Genistein can potentially have a beneficial effect on diabetes-induced dyslipidemia
Mehrasa Mohammadsadeghi, Niaz Mohammadzadeh Honarvar, Mostafa Qorbani, Anahita Mansouri, Fariba Kouhdani,
Volume 16, Issue 2 (9-2018)
Abstract
Background and Aim: Lipoprotein disorders are an integral component of type-2 diabetes mellitus (T2DM). Therefore, early diagnosis and treatment of lipid disorders can be beneficial in prevention and treatment of many complications associated with T2DM.The aim of this study wasto determine the effect of docosahexaenoic acid (DHA) supplementation on the serum levels of apolipoproteins (Apos) A1, A2, B48 and C3 in patients withT2DM.
Materials and Methods: In this 8-week randomized, double-blind, placebo-controlled clinical trial, 44 T2DMpatients were randomly assigned to either an experimental group (n=22, receiving daily 2.4 g DHA) or a placebo group (n = 22, receiving paraffin). The serum levels of AposA1, A2, B48 and C3 were measured in all the patients at the beginning and at the end of the period.
Results: There was a statistically significant increase in the mean serum level of ApoA1 in the DHA group (p = 0.014). In addition, a significant difference was observed in the serum level of ApoC3 after intervention between the DHA and placebo group (p=0.031). There were no significant differences between the two groups as regards the mean changes in serum levels of ApoA1, ApoA2, ApoB48 and ApoC3.
Conclusions: Dietary supplementation with docosahexaenoic acidhasno effects on the serum levels of apolipoproteins in patients with type-2 diabetes.
Mohammad Javad Kabir, Alireza Haydari, Mohammad Reza Honarvar, Zahra Khatirnameni, Abbas Badakhshan, Narges Rafiei, Sakine Beygom Kazemi, Seyed Mehdi Sedaghat, Mehrdad Kamangari, Masoumeh Gholami, Maryam Eri, Mansoureh Lotfi,
Volume 19, Issue 2 (9-2021)
Abstract
Background and Aim: The World Health Organization considers the implementation of the referral system to be a key step in improving the quality of services in health care systems. The purpose of this study was to explain the executive challenges of the electronic referral system in Golestan Province, Iran.
Materials and Methods: A qualitative study was conducted in Golestan Province, Iran in 2019 with a content analysis approach. The participants were family physicians, specialists, university staff managers, responsible health officers in the Offices of Deputy Ministers of Health, the General Directorate of Health Insurance, Department of Information Technology, Rural Health Network managers, health network managers and patients selected purposefully. Data were collected through semi-structured interviews and analyzed using the content analysis method.
Results: The main challenges of giving appointments to patients included the lack of time of family physicians, the irregular presence of specialists, difficulty in getting an appointment, and reverse referrals. As regards referrals and waiting times, the main challenges were found to be the lack of sufficient admissions following cancellation of the health insurance contract with the private sector, the delay of physicians in attending the health centers, long waiting times to be visited, and writing the feedback by the physicians. In addition, the main challenges of the visits and diagnosis included the short visiting times, the higher quality of the specialists' visits in the private sector, and the lack of clear guidelines. Finally, the main challenges as regards giving feedback were the reluctance and noncommitment of some specialists to provide feedback, as well as the low quality and lack of usability of the feedbacks given.
Conclusion: Based on the findings of this study, the following actions and measures may help improve the current situation as regards the current referral systems: allocating sustainable resources; allocating financial credits; designing and implementing a reward and punishment system; reforming the queuing system; empowering medical students; and equipping specialists with electronic pens for giving written feedback.
Mohammad Javad Kabir, Alireza Heidari, Nahid Jafari, Zahra Khatirnamani, Mohammad Reza Honarvar, Naser Behnampour,
Volume 19, Issue 4 (3-2022)
Abstract
Background and Aim: Using a proper method to prioritize and develop a basic health services package is a serious challenge. This study was conducted to design a process for developing and revising a basic health services package in Iran.
Materials and Methods: A combined study of quantitative and qualitative methods was used in this study. The qualitative part was conducted through holding 25 in-depth individual interviews and two focus group discussions with experts from the Ministry of Health and Medical Education, Program and Budget Organization and insurance organizations, while the quantitative part was a descriptive cross-sectional study including 277 experts using a valid and reliable questionnaire. Data analysis of the qualitative and quantitative parts was done using a content analysis and the SPSS-23 software, respectively.
Results: The process of developing a basic health services package includes 4 steps, namely, explaining the list of services in the basic health services package, extracting the criteria for including services in the service package, prioritizing the criteria for including services in the package, and comparing services with priority criteria. In the prioritization stage, disease burden criteria, target groups and community needs were found to have the highest means and recognized as the most important criteria.
Conclusion: The process designed in this study for developing and revising a basic health services package provides policymakers with the required scientific evidence by emphasizing the introduction and continuity of services that have higher priorities and the elimination of services that have lower priorities.
