Journal of School of Public Health and

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Background and Aim: In order to elucidate the role of vitamin D in the genesis of lung tumors, we used an experimental model of lung lesions in mice induced by the administration of urethane.
Materials and Methods: A total of inbred balb/c mice (male and female) 9-11 weeks old, were studied. They were divided into 3 groups. The first and second groups (U and U+D) were injected with urethane i.p, 600 mg/kg/day with 48 hours intervals for three times. The second group was given 3.5 mg/kg (6.3 mg/1000 ml) vitamin D with drinking water for 4 weeks after starting the injection by urethane.
Results: The third group served as control. Total remaining mice were killed after 20 weeks. Lung lesions were histopathologically characterized by hyperplasia, adenoma and adenocarcinoma in different groups. Tumor formation significantly increased in the urethane group as compared with control group (p<0.05) but there was not any difference between those receiving the (U+D) treatment group and the controls.
Conclusion: It seems vitamin D inhibites genesis of lung tamors induced by the administration of urethane.

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Background and Aim: To determin the most sensitive tissues to carcinogenic effect of urethane and co-carcinogenic effect of sodium nitrite by investigation of histopathological variations in different tissues of balb/c mice.

Materials and Methods: An experimental study in 40 inbred balb/c mice aged 9-11 weeks was designed. The samples were classified into 4 groups: The first group was mice treated with 50 mg/l sodium nitrite in 0.9% NaCl instead drinking water SN&NaCl). The urethane group (U) was characterized by intraperitoneal injection of 3 times urethane (600 mg/ kg/day at 48 hour intervals). The third group was given 50 mg/l sodum nitrite in drinking water (U&SN) following the same intake of urethane as the second group, and the forth one was the control group. All mice were sacrificed after 20 weeks tissues were removed and examined for histopathological changes. Data analyzed by Fisher exact test.

Results: The formation of lung tumor was, significantly, increased in the urethane group as compared with the control group & (NS+Nacl) groups ( respectively P<.004 & P<.02) and in (U+NS) group as compared with the control group & (NS+Nacl) groups ( respectively P<.003 & P<.02). In females mice also The formation of lung tumor was, significantly, increased in the urethane group as compared with the control group & (NS+NaCl) groups (P<.05) and in the (U+NS) group was significantly higher than those in (C) & (NS+NaCl) groups (P<.009). The formation of lung adenocarcinomas was, significantly, increased in the (U+NS) group as compaired with the (C) & (NS+Nacl) groups (P<.003). In females mice also the formation of lung adenocarcinomas was, significantly, increased in the (U+NS) group as compaired with the (C) & (NS+Nacl) groups (P<.009) and (U) group (p<.05).The frequencies of stomach and testis hyperplasia and metaplasia in different groups did not show any significant differences. There was no histopathological variation in other tissues.

Conclusion: Our results showed the tumorigenic effect of urethane in lung tissue. Sodium nitrite increases tumorogenic effect of urethan. Sodium nitrite increases carcinogenic effect of urethan (This result is the first study that suggest sodium nitrite increases carcinogenic effect of urethan).Urethan increases co-carcinogenic effect of sodium nitrite.

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Background and Aim: Weight status perception is an important factor in nutritional behavior. The aim of this study was to determine Islamshahr women's self-perception of their obesity status and perception of their husbands' opinions regarding women's obesity status, as compared with the actual central obesity status of the women.

Materials and Methods: This was a cross-sectional (descriptive-analytical) study carried out in 2003 on a cluster sample of Islamshahr women aged 20-65 years (n = 704). Data were collected by interviews and weight, height, and waist and hip circumferences were measured. A waist-to-hip ratio (WHR) greater than 0.849 was considered as central obesity. Based on the body mass index [BMI=weight/height²(kg/m²)],  underweight,  normal, overweight, and obese were defined as a BMI <18.5,  18.5-24.9 ,  25-29.9, and  ≥30, respectively.

Results: About 35% of the women with central obesity considered themselves underweight or normal. Married women's perception of husbands' opinions regarding their  obesity status showed about 45% misclassification. Women with central obesity who thought their husbands would assess them as underweight or normal were more likely [OR=18.6, 95% CI: 9.1 to 38.2] to underestimate their obesity status as well.

Conclusion: Misperception of obesity status is common among Islamshahr women. Considering the role of central obesity in metabolic diseases, menstrual disorders and increasing serum androgens, conducting nutrition education programs is essential for prevention and control of central obesity in the region studied.