E Jaberi , A Jazayery , A Mohagheghi , A Rahimi ,
Volume 2, Issue 2 (4 2004)
Abstract
On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a strong, independent risk factor for cardiovascular disease. Some studies have detected hyperhomocystememia in more than one - third of patients with coronary vascular disease. With an increase in total homcysteine (tHcy) concentration of 5 janol/L, the relative risk of cardiovascular disease has been estimated to increase by 60% for men and 80% for women. In a cross-sectional study we investigated tHcy concentration in 35-65 year-old ischemic heart patients (n=348, 157 men and 191 women) in a clinic in Tehran.
Fasting total homocysteine level was measured by high-performance liquid chromatography (HPLC) and using the internal method. The data were analyzed statistically using one-way analysis of variance (ANOVA) and the independent t-test. The results showed that while 18.96% of the patients had a normal tHcy level (<8 /imol/lit), in 27.52%, 50.52%, and 2.8 % of them the level was almost high (8-<12 /imol/L), high (12-<25 /imol/L), and abnormally (>25 /imol/L), resapectively. The mean tHcy concentration in men was significantly higher than in women ( P= 0.02). More extensive studies should be conducted to assess the tHcy status in the Iranian population at large.
H Zeraati , M Mahmoudi , K Mohammad, A Kazemnejad, M.a Mohagheghi , M.r Mir ,
Volume 3, Issue 4 (4 2005)
Abstract
In recent years the patterns of mortality have changed in Iran, and cancers are playing
a greater role in this regard in this country. Various reports indicate that gastric cancer
is highly prevalent it is the second most common cancer in men, and fourth in the
general population. The purpose of this study was to determine the five-year survival
rate of gastric cancer patients who had undergone surgical treatment at one of the
most important cancer treatment centers, the Iran Cancer Institute, and to assess its
associated factors.
Three hundred and 30 patients with gastric cancer who had been admitted to and
operated on at the Iran Cancer Institute between January 1996 and April 2000 were
enrolled in this study. The patients’ life expectancy after surgery was determined, and
its relationship with variables of age at the time of surgery, gender, and factors related
to the disease such as the cancer site, pathologic type, stage, presence of metastasis,
and sites of metastases were assessed.
The five-year survival rate and the median life expectancy in the studied patients were
23.6% and 19.90 months, respectively. Univariate analysis showed that gender,
cancer site, and pathologic type did not affect life expectancy significantly. But the
five-year survival rate significantly decreases with age. As expected, those involved
with metastasis had a significantly lower five-year survival rate, and the disease stage
significantly affected the patients’ life expectancy (P<0.001). The Cox proportional
hazards model was used to assess the effect of different variables simultaneously, and
it showed that age, distance metastasis, and disease stage influenced the rate of
survival.
Gastric cancer patients in Iran have a low five-year survival rate. One of the most
important reasons seems to be delayed consultation and diagnosis. Most patients are
seen first with the disease in the late stages. At this point, most have lymph node and
liver metastasis which makes treatment even more complex. Thus, it is necessary to
employ mass media for extensive public education about the early warning signs of
the disease and performing periodic examinations.
Soodeh Shadkam, Mehran Farhadi, Mohammad Reza Zoghi Paydar, Hossein Mohagheghi,
Volume 21, Issue 4 (3-2024)
Abstract
Background and Aim: Considering the high prevalence of anxiety disorders, the high comorbidity of social anxiety disorder and generalized anxiety disorder, and the negative and lasting effects of social anxiety disorder on various aspects of a person's life, the present study investigated the effect of emotion regulation group therapy on the symptoms of social anxiety disorder comorbid with generalized anxiety disorder.
Materials and Methods: This was a quasi-experimental study with a pre-test and post-test design with control and follow-up groups. The statistical population included all the patients with social anxiety disorder comorbid with generalized anxiety disorder referring to psychotherapy clinics in Shiraz, Iran, from among whom a sample of 30 people were selected by the available sampling method. Data were collected using Structured Clinical Interviews for DSM-5 (SCID-5), Generalized Anxiety Disorder Scale-7 and the Social Interaction Anxiety Questionnaire (SIAS) and analyzed with SPSS version 27 software using the analysis of variance method with repeated measurements
Results: The data obtained showed that emotion regulation group therapy could significantly reduce the symptoms of social anxiety disorder (p<0.001) and generalized anxiety disorder (p<0.001), the results remaining stable in a three-month follow-up (p<0.05)
Conclusion: Based on the findings of this study it can be concluded that group therapy of emotion regulation is effective in, and can, thus, be used as a therapeutic intervention for, social anxiety disorder comorbid with generalized anxiety disorder.
