Showing 3 results for Mohammadzadeh
Mohammad Hassan Eftekhari, Niaz Mohammadzadeh Honarvar, Abdolreza Rajaiefard, Ali Akbar Owji,
Volume 9, Issue 4 (13 2012)
Abstract
Background and Aim: It is known that oxidative stress plays an important role in the pathogenesis of diabetes. Consequently, use of antioxidant for treating and preventing complications of this disease is believed to be beneficial. Considering the antioxidant effects of soy isoflavones, this study was initiated to determine the effects of genistein, one of the isoflavones in soybeans, on serum glucose, lipid profile, and paraoxonase activity in diabetic rats.
Materials and Methods: Thirty-six male Sprague Dawley rats were divided randomly into three groups, in 2 of which diabetes was induced by intravenous injection of 60 mg/kg body weight stereptozotocine dissolved in a 0.05 mol/liter citrate buffer the criterion for diabetes was a plasma glucose level above 250 mg/dl. All the 3 groups were fed a standard diet for 3 weeks, genistein (95% purity) being added to the diet of one of the diabetic groups at a level of 600 mg/kg diet. Fasting blood samples from the tail were taken at baseline and at the end of the period for measuring glucose, lipids, and paraxonase activity. The statistical test used for data analysis and inter-group comparisons was ANOVA.
Results: Supplementation with genistein had no statistically significant effects on the serum paraxonase activity or glucose level, but it brought about significant decreases in the serum triglyceride and total, HDL- and LDL-cholesterol levels.
Conclusion: Genistein can potentially have a beneficial effect on diabetes-induced dyslipidemia
Mehrasa Mohammadsadeghi, Niaz Mohammadzadeh Honarvar, Mostafa Qorbani, Anahita Mansouri, Fariba Kouhdani,
Volume 16, Issue 2 (9-2018)
Abstract
Background and Aim: Lipoprotein disorders are an integral component of type-2 diabetes mellitus (T2DM). Therefore, early diagnosis and treatment of lipid disorders can be beneficial in prevention and treatment of many complications associated with T2DM.The aim of this study wasto determine the effect of docosahexaenoic acid (DHA) supplementation on the serum levels of apolipoproteins (Apos) A1, A2, B48 and C3 in patients withT2DM.
Materials and Methods: In this 8-week randomized, double-blind, placebo-controlled clinical trial, 44 T2DMpatients were randomly assigned to either an experimental group (n=22, receiving daily 2.4 g DHA) or a placebo group (n = 22, receiving paraffin). The serum levels of AposA1, A2, B48 and C3 were measured in all the patients at the beginning and at the end of the period.
Results: There was a statistically significant increase in the mean serum level of ApoA1 in the DHA group (p = 0.014). In addition, a significant difference was observed in the serum level of ApoC3 after intervention between the DHA and placebo group (p=0.031). There were no significant differences between the two groups as regards the mean changes in serum levels of ApoA1, ApoA2, ApoB48 and ApoC3.
Conclusions: Dietary supplementation with docosahexaenoic acidhasno effects on the serum levels of apolipoproteins in patients with type-2 diabetes.
Homeira Soleimannejad, Hamid Poursharifi, Jahansha Mohammadzadeh, Kourosh Sayemiri,
Volume 17, Issue 1 (6-2019)
Abstract
Background and Aim: Adolescents' attitude to suicide is one of the major problems in mental health. Thus, research in this area is of utmost importance. The objective of this study was to determine the effectiveness of an integrated protocol in reducing the negative attitude toward problem solving as a determinant of suicidal tendency in adolescents and young people 15-24 years old in Ilam, Iran.
Materials and Methods: In this semi-experimental pretest-posttest study with a control group, a sample of 40 adolescents 15-24 years old were selected by random cluster sampling in Ilam city, Iran. All of the participants completed a suicidal attitude questionnaire, as well a negative- attitude-toward-problem solving questionnaire. Data were analyzed using the SPSS-V19 software, the statistical test being the multivariate covariance analysis (MANCOVA).
Results: Multivariate analysis of variance analysis showed that there was a significant difference in the attested scores of the two groups (P <0.01, F = 0.408, Wilk's Lambda = 0.506). The differences between the experimental and control groups were significant as regards all of the components of the negative attitude. The training based on the integrated approach to negative attitude in problem solving was found to have been effective. The post-test scores of two variables, namely, problem tendency-avoidance and personal control, decreased in the experimental group; however, one other variable, namely, trust in problem-solving, increased.
Conclusion: Based on the findings it can be concluded that education based on an eclectic (integrated) approach towards the negative attitude to problem solving can be effective in adolescents and the youth 15-24 years old with suicidal tendencies ─ suicidality. Hence, it is recommended to administer training programs such as problem-solving, emotional regulation and mindfulness to help psychologists, parents, adolescents, health professionals and social pathologists to reduce and prevent suicide in adolescents.
