Journal of School of Public Health and

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Background and Aim: The aim of this study is to evaluate the familial aggregation of esophageal cancer in a defined population under coverage of Babol Research Station, Institute of Public Health Research, Tehran University of Medical Sciences, in one of the high incidence areas in north of Iran and to assess the risk of disease associated with first degree familial relationship.
Material and Methods: In this study, the data of family members of three to four successive generations and family history of esophageal and other cancers were collected from esophageal cancer cases which occurred between 2001-2003 in Babol district. The pairwise odds ratio of logistic regression method with GEE2 approach used for familial aggregation of esophageal cancer within first degree family. The results have been adjusted on covariates of age and sex of each family member and age and sex of the proband .
Results: The proportion of having a positive family history of esophageal cancer in first relatives is 3.09% (3.8 % in men and 2.3 % in female relatives). The pairwise odds ratio was 1.79 (95% CI :1.1 , 2/93) in first degree family and odds ratio between parent – offspring was 2.21 (95%CI :1.1 , 4/44)and relation between sibling was 1.92(95%CI: 0.87, 4.24) . It was not possible to look for any parent – parent pattern.
Conclustin: We found a familial aggregation between first degree relatives in this area.The association between parent–offspring suggests the presence of a genetic component in this disease.

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Background and Aim: Premenstrual Syndrome (PMS) is experiencing some physical and psychological symptoms in the last days of the menstrual cycle; it interferes with educational, social and family functioning, creating problems for the adolescents. The objective of this study was to determinee the effectiveness of a transdiagnostic treatment program on anxiety, depression and stress in female adolescents with premenstrual syndrome and their mothers' quality of life.
Materials and Methods: This experimental study was conducted on 26 female adolescents with PMS referring to two health centers in Tehran, Iran in 2019. They were divided randomly in 2 groups, namely, an intervention (n=12, attending six 90-minute session per week‎) and a control (n=14) group. Data were gathered using the WHO Quality of Life, Beck depression, the DASS and PMS Screening Tool (PSST) questionnaires initially and after one month. The repeated ANOVA test was used for data analysis using SPSS software version 21; a p-value of <5% was considered to show statistical significance.

Results: As compared to the control group, at the end of the period the intervention group showed a statistically significant decrease in the means of the three variables of depression, anxiety and stress (p <0.05). The decrease significantly improved the quality of life of the mothers.

Conclusion: The findings of this study show that a transdiagnostic treatment program can be an effective method to reduce the psychological problems of adolescent girls and improve the quality of life of their mothers.