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Rezvan Kakavand-Ghalehnoei, Zabihallah Shoja, Alireza Najafi, Mostafa Haji Mollahoseini, Somayeh Jalilvand,
Volume 14, Issue 3 (12-2016)
Volume 14, Issue 3 (12-2016)
Abstract
Background and Aim: Considering the lack of information on the occurrence of the epidemic form of Kaposi’s sarcoma (KS) and the high prevalence of human herpesvirus 8 (HHV-8) infection among human immunodeficiency virus (HIV)-infected patients (46%), it was decided to estimate the incidence of KS in this group. Based on the fact that active HHV-8 infection leads to KS development, it is essential to first assess the prevalence of active HHV-8 infection in these patients. Most of the Iranian HIV-infected patients are not aware that they are HIV-positive. If the prevalence of HHV-8 infection is high in these patients, they may spread HHV-8 in the community by high-risk sexual behaviors, which would lead to an increase in the incidence of classic Kaposi’s sarcoma. The objective of this study was to investigate the prevalence of HHV-8 among HIV-infected subjects.
Materials and Methods: One-hundred plasma samples from HIV-infected patients were collected. Genome was extracted and assessed by the nested PCR assay with specific primers for ORF26. Positive samples were amplified for the ORF K1 region by nested-PCR. Subsequently their products were sequenced and their phylogenic trees constructed.
Results: HHV-8 was detected in 8 of the patients (8%). No statistically significant associations were found between age and gender on the one hand and HHV-8 infection on the other (p > 0.05). Two genotypes, namely, A and C, were identified, the former in two patients and the latter in one.
Conclusion: Although the prevalence of HHV-8 infection is high among Iranian HIV-infected patients, active HHV-8 infection rate is low among them. Therefore, it seems that the incidence of epidemic KS is likely to be very low in this group. Certainly more research is needed in this area. As regards genotypes, genotypes A and C are found in the samples.
Sanaz Nargesi, Parivash Koordbacheh, Shirin Farahyar, Fatemeh Noorbakhsh, Sasan Rezaie,
Volume 14, Issue 3 (12-2016)
Volume 14, Issue 3 (12-2016)
Abstract
Background and Aim: Considering the increasing drug resistance to Aspergillus fumigatus,
search for genes involved in its pathogenicity and identifying alternative antifungal drugs is of utmost importance. The aim of this study was to determine the effects of diclofenac sodium on the growth and sidB gene expression in Aspergillus fumigatus.
Materials and Methods: In this study, Aspergillus fumigatus was cultured and a fungal suspension prepared, followed by determining the minimum inhibitory concentration of diclofenac sodium at a concentration of 25-1000 µg/ml. Then, RNA was extracted from the suspension at concentrations of 500,700 and 900 µg/ml of the drug. Finally, the extent of expression of the gene was determined by measuring different levels of mRNA-sidB by Real-time PCR.
Results: With increasing concentrations of diclofenac sodium, mycelium production decreased. Concentrations higher than 500 µg/ml had considerable inhibitory effects on the growth of Aspergillus fumigatus.
Conclusion: Findings of this study indicate that diclofenac sodium can cause a sharp reduction in the growth rate of Aspergillus fumigatus. Accordingly, it can be considered as one of the effective pharmacological agents for inhibiting the growth of this fungus.
Farzaneh Soltanipour, Behzad Damari,
Volume 14, Issue 4 (3-2017)
Volume 14, Issue 4 (3-2017)
Abstract
Background and Aim: Sustainable development to address the global economic, environmental and social issues has been introducedby prominent scientists and is widely used by governments, international organizationsand NGOs. This study aimed to assess the current sustainable development situation influencing health and the future of health in Iran.
Materials and Methods: This was a descriptive study. The sample size was determined using the targeted intentional method and data were collected through targeted search, semi-structured interviews and focus group discussions.
Results: Sustainable development situation in the country has improved in terms of quantitative indicators of child and maternal mortality and Human Development Index.Have However, badair quality, unemployment, inflation and other social harms have had undesirable trends.The most important causes of slow sustainable development have been reliance on oil revenues, unemployment, increased inflation, inequity in incomes, poverty, and insufficient intersectoral coordination due to lack of a multi-ministerial secretariat. The health sector should have a comprehensive approach to promoting health of the population.
Conclusion: Based on the findings, it is recommended to include training courses for managers based on sustainable development principles, as well as management techniques in academic training and in-service training of managers. It is essential to create a multi-ministerial infrastructure and, even, a infrastructural power, for cohesion and coordination in order to ensure sustainable development.
Beyram Bayat, Bahram Mohebbi, Azar Tol, Roya Sadeghi, Mir Saeid Yekaninejad,
Volume 15, Issue 4 (3-2018)
Volume 15, Issue 4 (3-2018)
Abstract
Background and Aim: Quality of life is considered as an effective indicator for general, as well as mental, health. With increasing longevity of individuals, health-promoting behaviors and rising quality of life will become much more important. This study aimed to determine the quality of life predictors among health volunteers in South Tehran Health Centers.
Materials and Methods: : This cross-sectional study was conducted on 200 health volunteers of South Tehran Health Centers selected by cluster sampling. Data were collected using valid and reliable questionnaires for demographic variables, Health-promoting Behaviors (HPLPII) and Quality of life (SF-36), as well as the BAZNEF model constructs, whose validity and reliability were assessed (α: %88). Data analysis was done using the SPSS24 software, the statistical tests being descriptive statistics and multi-linear regression; a p-value <0.05 was used to show statistical significance.
Results: Regression analysis revealed that the strongest predictors for the quality of life were age (p=0.003), enabling factors (p=0.02) and general health-promoting behaviors (p<0.001).
Conclusion: The findings of this study confirm the suitability of the BAZNEF model for predicting health-promoting behaviors for the quality of life. Using this model can help in identifying factors influencing the quality of life of health volunteers and designing an appropriate educational program for them.
Azar Tol, Bahram Mohebbi, Elham Shakibazadeh, Mehdi Yaseri, Maryam Sabouri,
Volume 16, Issue 2 (9-2018)
Volume 16, Issue 2 (9-2018)
Abstract
Background and Aim: In health promotion, empowerment is a process through which people gain greater control over decisions and actions affecting their health. This study aimed to assess the predictive factors of health care empowerment among women in reproductive age in 2016.
Materials and Methods: This cross-sectional study was conducted on 549women in reproductive age referring to health centers in South Tehran. The participants were recruited through cluster and multi-stratified sampling. Data were collected using the Health Care Empowerment Questionnaire (HCEQ), which has three subscales, namely, degree of control, involvement in interactions and involvement in decision-making. The data were analyzed using the descriptive and analytical tests and multi-regression analysis.
Results: Husbands' education level, women's employment, family size, ethnicity, history of chronic diseases and economic status were predictors of degree of control. Husbands' education level (under high school diploma and high school diploma), family size (2-3, 3-4) and moderate economic status (sufficient income) predicted involvement in interactions. In addition, husbands' education (incomplete high school diploma and high school diploma), family size (2-3, 3-4), women's employment and history of chronic diseases predicted involvement in decision-making.
Conclusion: The findings indicate that various individual, family and socio-economic conditions of reproductive-age women influence their potential empowerment for receiving health care services. A family-based approach to facilitate receiving reproductive health care seems to be essential.
Mohsen Roshanpajouh, Roksana Mirkazemi, Mehrdad Ehterami, Houman Narenjiha, Hossein Malek Afzali, Hamidreza Sarrami, Majid Rezazadeh, Fatemeh Abbasi, Saeid Noroozi,
Volume 16, Issue 4 (3-2019)
Volume 16, Issue 4 (3-2019)
Abstract
Background and Aim: Drug abuse is a long-standing social and public health problem in Iran. Access to accurate, reliable and up-to-date data related to drug use is essential for planning and policy-making for prevention of, treatment of, and harm reduction related to, drug abuse. The purpose of this study was to access accurate data regarding drug abuse prevalence and substance use in Tehran Province population.
Materials and Methods: This study was a cross-sectional household survey with a sample of 6024 individuals aged 15-64 years residing in Tehran Province. Data on demographic characteristics and drug use during the previous week, month and year and the whole lifetime were collected using a researcher-designed questionnaire.
Results: A total of 5646 individuals participated in the study. The lifelong prevalence of cigarette-smoking, hookah-smoking, alcohol consumption and drug use were 21.9%, 26.8%, 12.1% and 7.3%, respectively. The corresponding proportions during the previous week were 12.9%, 10.5%, 1.8% and 2.2%.
Conclusion: The prevalence of cigarette-smoking, hookah-smoking, alcohol consumption and drug use is high in Tehran Province. The prevalence of lifelong cigarette and hookah smoking and alcohol consumption is higher, while that of drug use is lower, than the respective national averages.
Sajjad Dorri Kafrani, Atefeh Zolfagharnasab, Fatemeh Torabi,
Volume 17, Issue 2 (9-2019)
Volume 17, Issue 2 (9-2019)
Abstract
Background and Aim: Along with the expansion of health systems, the importance of primary health care as the basis of an efficient health system is more evident and the quality of the provided services at this level becomes more important. In this way, the present study attempts to collect patterns used to improve the quality of primary health care.
Materials and Methods: The present study is a systematic review. The advanced search was done in the Web of Science, Scopus, Embase, PubMed, Cochrane, SID, MagIran, IranDoc, and Google Scholar databases in title, abstracts and keywords fields. Inclusion criteria include a comprehensive attitude, focus on primary health services, English or Persian language, published between 2006 and 2018. Exclusion criteria include studies that focus outside of primary health care. The quality of the studies was evaluated using the JBI checklist. Two independent researchers conducted the task of selecting studies, extracting data and evaluating the quality of studies, and disagreement cases were resolved by the third researcher.
Results: After screening and reviewing the criteria for the entry of 10095 studies, 11 studies were finally included. The quality of the four studies was evaluated average and the rest of the quality was high. Two studies have provided patterns for improving the quality of primary health care, three evaluated the effectiveness of quality improvement tools, and five presented conceptual frameworks.
Conclusion: A total of eight types of systems extracted to assess and improve the quality of primary health services. Studies on primary health care have been used at various levels of personal, professional, practical and national policy, and have developed models, tools and frameworks that each of them can be used separately or combined for different situations with regard to the limitations and facilities mentioned and improve health outcomes.
Neda Karimi, Shahrzad Saadat Gharin, Azar Tol, Roya Sadeghi, Mehdi Yaseri, Bahram Mohebbi,
Volume 17, Issue 3 (12-2019)
Volume 17, Issue 3 (12-2019)
Abstract
Background and Aim: Since many of the healthy behaviors are adopted and develop during adolescence, proper choice of such behaviors is very important in this period of life. In addition, paying attention to the health of girls is crucial because they will transfer such behaviors to the next generation. Therefore, this study aimed to identify the role of health literacy and demographic variables in determining health-promoting behaviors among second-grade high school girl students in the City of Tehran, Iran.
Materials and Methods: This descriptive-analytic cross-sectional study was conducted on 370 female students using cluster sampling method in 2018. Data were collected using demographic, Health Literacy Measure for Adolescents (HELMA) and Health-Promoting Lifestyle Profile II (HPLPII) questionnaires and analyzed using SPSS25.
Results: The results of multivariate regression analysis revealed that there were statistically significant direct associations between health-promoting behaviors and the following variables: one’s health literacy (β= 0.39, p<0.001), interest in health topics (β= 1.35, p<0.001), reading of journals and newspapers (β=0.76, p= 0.007), father's education (p= 0.002), body mass index (p= 0.022), field of study (p<0.001), the first source of health information (p<0.001) and place of residence (p = 0.023). Further analysis of the data showed an indirect association between health-promoting behaviors and age (β= -1.69, p<0.001) and health assessment (β=-1.67, p<0.01).
Conclusion: Based on the findings it is concluded that the subjects’ health literacy and health-promoting behavior scores were “not sufficient” and “intermediate”, respectively. It is recommended to design and implement appropriate training/intervention programs aiming at increasing the heath literacy and promoting health behaviors of female students.
Hojjat Rahmani, Farshid Nasrolah Beigi, Somayeh Nikan, Ghasem Rajabi Vasoukalaei,
Volume 17, Issue 3 (12-2019)
Volume 17, Issue 3 (12-2019)
Abstract
Background and Aim: Human resources are of paramount importance in the success of any organization. In the health care system, nurses play a great role in the delivery of high-quality care. In this regard, in the process of providing high-quality and efficient healthcare delivery, justice perception of performance appraisal system and organizational citizenship behavior (JPPAS & OCB) are strong tools for performance management. The aim of this study was to determine the association between JPPAS & OCB among nurses in Tehran University of Medical Sciences hospitals in Tehran, Iran.
Materials and Methods: This was a cross-sectional study with a sample size of 346 nurses working in Tehran University of Medical Sciences hospitals. Data were collected using two questionnaires, namely, the JPPAS & OCB and a general demographic questionnaire. SPSS 24.0 for windows was used for statistical analysis of the data.
Results: Analysis of the data showed that justice perception of performance appraisal system (2.70) and organizational citizenship behavior (2.66) are at a moderate level. Based on the correlation analysis, a significant positive association was found between performance appraisal and organizational citizenship behavior. In the final analysis it was shown that performance appraisal could predict organizational citizenship behavior (30.9% of the variance).
Conclusion: Justice perception of performance appraisal system can positively influence loyalty, job satisfaction and employees’ commitment, as well as create organizational confidence, enhance productivity and improve participation.
Leila Allahqoli, Azam Rahmani, Reza Ghanei Gheshlagh, Arezoo Fallahi, Masoumeh Hashemian, Hamed Fallahi, Babak Nemat-Shahrbabaki,
Volume 17, Issue 3 (12-2019)
Volume 17, Issue 3 (12-2019)
Abstract
Background Aim: Job burnout among health educators is increasing with serious physical, psychological and social consequences. The purpose of this study was to explore the causes of job burnout from the perspective of health educators and identify their needs for reducing it.
Materials and Methods: This qualitative study was carried out in comprehensive health service centers of Sanandaj, west of Iran, in 2017, including 15 health educators selected by purposive sampling. The data were collected through individual interviews and semi-structured group discussions, observation and field notes and analyzed using the conventional content analysis approach with due consideration of acceptability, verifiability and transferability to ensure the accuracy and strength of the data.
Results: The causes of job burnout were extracted in 5 categories including "issues related to comprehensive health service centers", "individual challenges of staff members", "management weakness", "executive system challenges" and "issues related to clients". The participants emphasized the following actions for reducing job burnout: strengthening individual skills, effective evaluation and management support, providing recreational and welfare facilities, reducing job stress, and strengthening intra- and inter-sectoral communications.
Conclusion: The results of this study show that various factors contribute to job burnout among health educators. Improvements in management, laws and welfare facilities not only would reduce job burnout but also may increase the efficiency of health education programs.
Azar Tol, Maryam Sabouri, Bahram Mphebbi, Elham Shakibazadeh, Mehdi Yaseri,
Volume 18, Issue 2 (9-2020)
Volume 18, Issue 2 (9-2020)
Abstract
Background and aim: Despite rapid diagnostic and therapeutic advances, patients with chronic coronary artery disease (CCAD) should adopt self-care behaviors. This study aimed to determine predictors of perceived health competence among CCAD patients in Tehran, Iran in 2019-2020.
Materials and Methods: This cross-sectional study was conducted among 700 patients with CCAD referred to Shahid-Rajaie Cardiovascular Center in Tehran selected using the available sampling method. Data were collected using the perceived health competence scale (PHCS), 12-item quality of life scale and Modanloo's adherence to treatment scale questionnaires. The content validity ratio and content validity index were used to determine validity, and the Cronbach's alpha to determine reliability, of the PHCS questionnaire. Data analysis was performed using descriptive statistics, Pearson correlation coefficient, Structural Equation Modeling (SEM), the software being SPSS25.
Results: The multivariate regression analysis showed that perceived health competence had statistically significant direct associations with physical (β = 1.08, p< 0.001) and psychological (β = 0.85, p< 0.001) domains of quality of life, commitment to treatment (β = 0.12, p =0.01), willingness to participate in treatment (β = 0.12, p = 0.05) and uncertainty about implementation (p = 0.1, p‹ 0.001) of adherence to treatment. There was a significant indirect association between age and perceived health competence (β = -0.13, p = 0.03).
Conclusion: Based on the findings, considering a “very good” and a “poor” mean score for adherence and the quality of life among the patients, respectively, adopting strategies for promoting quality of life in both the physical and mental dimensions can lead to improvements in perceived health competence in cardiovascular patients. In addition, it seems that focusing on subscales of “willingness to participate in treatment” might help in improving the patients' perceived health competence.
Mehdi Khoshgoo, Mojtaba Khadem Al-Hosseini , Rahman Panahi, Farzad Shidfar, Parvin Hasanzadeh,
Volume 18, Issue 3 (11-2020)
Volume 18, Issue 3 (11-2020)
Abstract
Background and Aim: Considering the importance of children's dietary patterns in the general health and vitality of the population in the future and the effect of maternal depression on performing maternal tasks and responsibilities regarding children's eating habits and behaviors, this study was designed and conducted to determine the relationship between maternal depression and children's dietary patterns.
Materials and Methods: This cross-sectional descriptive-analytical study included 313 primary school children in Tehran in the first semester of the academic year 2018-2019 selected through stratified cluster sampling. The following questionaires were used to collect the data: general and demographic questionnaires related to mothers and children, the Beck standard questionnaire to assess maternal depression, and a food frequency questionnaire to assess the children’s food patterns. The SPSS-22 and Stata-13 were used to analyze the data. Using exploratory factor analysis the dominant food patterns of the children were determined. The statistical tests used for data analysis included descriptive statistics, Mann-Whitney, Kruskal-Wallis and Pearson and Spearman correlation coefficients.
Results: Data analysis showed the prevalence of depression among the mothers and the dominant dietary pattern among the children to be 31.3% (n=98) and vegetarian dietary patterns, respectively. The children’s body mass index, heights and waist circumference were significantly positively associated with with some of the dietary patterns (p<0.05). However, no significant association was found between maternal depression and the children's dietary patterns (p>0.05).
Conclusion: According to the findings of this study, maternal depression has no significant association with children's dietary patterns. Conducting similar studies with larger sample sizes are recommended.
Saeedeh Pakdel Varjoei, Azar Tol, Roya Sadeghi, Mir Saeed Yekaninejad, Bahram Mohebbi,
Volume 18, Issue 3 (11-2020)
Volume 18, Issue 3 (11-2020)
Abstract
Background and Aim: Patient education is an essential component of diabetes control, and increasing the health knowledge of diabetic patients based on suitable educational theories is crucial. This study aimed to determine the effect of educational intervention using the Transtheoretical Model (TTM) on improving the nutritional habits among patients with type-2 diabetes mellitus in Maragheh city, Iran during 2017-2018.
Materials and Methods: This study was a randomized controlled trial conducted on 136 diabetic patients under coverage of Maragheh health centers, Maragheh city, Iran, randomly divided into two groups of intervention and control (68 participants in each group). The data collection tool was a three-part questionnaire with questions/items related to demographic characteristics and nutritional habits, as well as constructs of TTM and HbA1c based on the TTM. The educational program included four weekly sessions of 45-60 minutes each. The data were analyzed using the SPSS16 software, the statistical tests being descriptive and inferential tests such as ANCOVA; the significance level was set as a p-value < 0.05.
Results: Before the intervention, the comparison and control groups did not differ significantly as regards demographic variables, HbA1c, TTM constructs and nutritional habits (p<0.05). After the educational intervention, the mean scores of nutritional habits, constructs of TTM and HbA1c were statistically significant in patients with type 2 diabetes (p <0.01).
Conclusion: The study results reveal that the application of transtheorical model can improve the nutritional habits of diabetic patients.
Zahra Jamshidi, Bahram Mohebbi, Elham Shakibazadeh, Azar Tol, Mehdi Yaseri,
Volume 19, Issue 1 (6-2021)
Volume 19, Issue 1 (6-2021)
Abstract
Background and Aim: Patients with diabetes need continous support for sustainable self-care behaviors. The use of supportive forces to improve the level of self-management of diabetes is felt. The aim of this study was to compare the effectiveness of direct and indirect virtual educational interventions on the promotion of self-management behaviors and diabetes control in women with type 2 diabetes. The study was conducted in 2019.
Materials and Methods: This clinical trial study included 100 females with type 2 diabetes under the coverage of three health centers affiliated to Tehran University of Medical Sciences, randomly divided into two groups of direct and indirect education (50 subjects in either group). A questionnaire was used as the standard tool of diabetes self-management. The education imparted to the subjects was based on the latest version of Diabetes Self-Management Education (DSME), and the educational sessions were based on the Stanford University's self-management model, including six 90-minute sessions during three weeks. Data were analyzed using SPSS-16 statistical software, the statistical tests being covariance analysis, etc.
Results: There were no statistically significant differences between the direct and indirect educational groups as regards the self-management scores and HbA1c levels in the first and second pre-tests (p<0.05). However, both the self-management scores and HbA1c levels of the two groups, determined at 3- and 6-month follow-ups, were found to be statistically significantly different (p<0.05).
Conclusion: The findings of this study indicate the feasibility of using volunteers, after empowering them properly, to implement diabetes self-management educational interventions.
Behzad Damari, Seyed Hasan Emami Razavi, Ahmad Hajebi, Elham Elahi,
Volume 19, Issue 2 (9-2021)
Volume 19, Issue 2 (9-2021)
Abstract
Background and Aim: According to the definition proposed by WHO, social health is a health dimension that impacts, or is affected by, the two physical and mental dimensions. Based on the definition given by the Academy of Medical Sciences of Islamic Republic of Iran, social health includes reciprocal qualitative and quantitative behaviors by individuals towards welfare of the society. Pro-social behaviors and an encouraging environment are considered as the two main components of social health promotion. The purpose of this study was to identify pro-social behaviors in the Iranian society.
Materials and Methods: This was a qualitative study. Data were collected using 1). Literature review based on sources related to Iranian culture and religious advice, as well as published international experiences, and 2). Expert opinions based on focus group discussions on eight specialized disciplines. The data obtained were content analyzed.
Results: Analysis of the data of this study showed twenty pro-social behaviors (possible to be categorized into three domains/areas of social thinking, speech and expression, and behavior):
acceptance of diversity and altruism, understanding human rights, not telling lies, cooperation, humbleness, donation/free contribution, being critical, patience and forgiveness, lack of distrust/suspicion, speaking competence, proper balance/equilibrium, sense of responsibility, brotherhood, personal discipline/order, fidelity, trustworthiness, consultation, cultural exchange, self-identity and, finally, respecting the environment.
Conclusion: Behavior change requires applying evidence-based models, e.g., social marketing. It is, thus, suggested that after investigating and surveying pro-social behaviors in the Iranian society, barriers to pro-social behaviors should be investigated and social marketing programs be developed and implemented aiming to help improve these behaviors.
Arezu Amirali, Ameneh Elikaei, Roxana Mansour Ghanaie, Idesbald Boone, Abdollah Karimi, Tim Eckmanns, Andreas Lutz Jansen, Fatemeh Fallah, Noushin Marhamati, Niloofar Pashaei, Shahriar Janbazi, Ahmad Reza Shamshiri, Hamid Reza Baradaran, Mohammad Hossein Rostami, Masoud Alebouyeh,
Volume 19, Issue 4 (3-2022)
Volume 19, Issue 4 (3-2022)
Abstract
Background and Aim: The objective of this study was to determine the seroepidemiological history of SARS-CoV-2 infection among asymptomatic children in Tehran.
Materials and Methods: Blood samples of children younger than 14 years old were collected during the period autumn-winter 2020 and spring 2021 and tested for SARS-CoV-2 IgG antibody using the EUROIMMUN ELISA kit. In addition, questionnaires were used to collect demographic and infection status information in the participants. Data were analyzed using the SPSS software.
Results: Out of the 1142 children collected from the children with no COVID-19 symptoms, 33.3% (381/1142) were found to have had a history of SARS-CoV-2. The positive samples in girls and boys were 34.1% and 33.03%, respectively. Analysis of the data showed no statistically significant differences between the infection rate on the one hand and age, family size, underlying diseases, gender or occupations of the family members on the other hand. In addition, the infection rate was significantly lower in autumn 2020 than in winter 2020 and spring 2021.
Conclusion: SARS-CoV-2 infection can occur in children with no clinical symptoms. In addition, the infection rate is in direct correlation with an increase in age of the children.
Banafsheh Taqfaghodi, Bahram Mohebbi, Roya Sadeghi, Azar Tol, Mir Saeed Yakanejad,
Volume 19, Issue 4 (3-2022)
Volume 19, Issue 4 (3-2022)
Abstract
Background and Aim: Cardiovascular diseases are the most common cause of death in most countries of the world, hypertension being the most important cause of disability. The aim of this study conducted in 2020-2021 was to determine the effect of educational intervention on the nutritional knowledge, illness perception and dietary adherence in hypertensive middle aged women based on the transtheoretical model (TTM).
Materials and Methods: This was a quasi-experimental study on middle-aged women (30-59 years old) suffering from hypertension referred to the health centers and health bases in the 21st district of Tehran in 2020-2021. A total of 164 subjects were randomly assigned to the intervention (n=82) or control (n=82) group by randomized quadruple blocks. A multifaceted questionnaire was completed for both the control and intervention groups and their blood pressure measured. This was followed by a one-month virtual education for the intervention group in the form of a WhatsApp group and designing and developing fifty-six podcasts and educational clips with a maximum duration of four minutes based on the transtheoretical model constructs. After a lapse of one and six months both groups completed the questionnaire again and their blood pressure was measured. Descriptive statistics and general linear model were used for data analysis using the SPSS version 25 (p<0.05).
Results: Before the intervention the mean age of the subjects was 50.16 years and their systolic and diastolic blood pressures were 1.35 and 1.84 mmHg, respectively, and there were no statistically significantly differences between the two groups as regards contextual variables, constructs of nutritional awareness, disease perception, diet adherence, systolic and diastolic blood pressures and body mass index (as an ananthropometric index) and transtheoretical model constructs. Data one month after the intervention revealed significant differences (p<0/001) between the two groups (p <0/001) as regards the constructs of nutritional awareness, disease perception, self-sufficiency construct of the transtheoretical model and systolic blood pressure. Six months after the intervention significant differences were observed between the two groups as regatds nutritional awareness constructs, disease perception (p<0.007), diet adherence (p<0.001), stages of change constructs (p<0.001) and self-sufficiency (p<0.001) of the transtheoretical model.
Conclusion: The results of this study show that educational intervention based on the transtheoretical model in middle-aged women with hypertension can increase their nutritional knowledge, illness perception, self-sufficiency, self-adequacy and diet adherence.
Zahra Tavakoli, Bahram Mohebbi, Roya Sadeghi, Azar Tol, Mirsaeed Yekaninejad, Masoud Alimardi,
Volume 20, Issue 1 (6-2022)
Volume 20, Issue 1 (6-2022)
Abstract
Background and Aim: Physical activity and nutrition are important topics in adolescent health. This study aimed to determine the predictors of nutritional knowledge, behaviors, and physical activity in fifth-grade elementary school female students
Materials and Methods: This cross-sectional descriptive-analytical study was performed on 480 female students in the fifth grade of the elementary school in Gods city in 2020-2021 by cluster random sampling. Data were collected using a researcher-made questionnaire two-part questionnaire of contextual questions and questions about knowledge, nutritional and physical activity, virtual in the Shad messenger. The content validity ratio and content validity index was used to determine validity, and the intra-cluster correlation index to determine the reliability, of the questionnaire. In data analysis, descriptive statistical tests, Pearson
correlation coefficient, and multiple regression analysis were performed using SPSS 27.Materials and Methods: This cross-sectional descriptive-analytical study was performed on 480 female students in the fifth grade of the elementary school in Gods city in 2020-2021 by cluster random sampling. Data were collected using a researcher-made questionnaire two-part questionnaire of contextual questions and questions about knowledge, nutritional and physical activity, virtual in the Shad messenger. The content validity ratio and content validity index was used to determine validity, and the intra-cluster correlation index to determine the reliability, of the questionnaire. In data analysis, descriptive statistical tests, Pearson
Results: The results of multiple regression analysis showed the effect of nutritional knowledge variables on nutritional behavior (p <0.001, β = 0.159) and physical activity knowledge on nutritional behavior (p = 0.008, β = 0.120) if the Physical activity knowledge variable was not effective on physical activity behavior and also nutritional knowledge variable had no effect on physical activity behavior.
Conclusion: Increasing knowledge of nutrition and physical activity improves students' nutritional behavior, but this increase in knowledge does not affect physical activity behavior. The sedentary lifestyle and the presence of the Covid-19 pandemic appear to have significantly reduced physical activity. By increasing knowledge, nutritional behavior and physical activity can be improved to some extent
Zahra Validabady, Mozhgan Lotfi,
Volume 20, Issue 1 (6-2022)
Volume 20, Issue 1 (6-2022)
Abstract
Background and Aim: Among the valuable developments in the primary health care system has been the special attention paid to the issue of mental health and the addition of a self-care program for community mental health education. However, no integrated measures have been taken in relation to the needs of service recipients, educational priorities and the required facilities. This study was conducted to explain the priorities of this program in primary health care centers affiliated to Iran University of Medical Sciences, Tehran, Iran.
Materials and Methods: This was a qualitative study with a content analysis approach. The sample consisted of 12 stakeholders selected by purposive sampling with maximum diversity. Data were collected through in-depth and semi-structured interviews and a modified checklist of the Community Health Needs Assessment Program and analyzed using the Granheim and Landman approach.
Results: Based on data analysis, the needs were grouped into two main categories, namely, the needs of service providers and the needs of service recipients. The service providers’ needs included continuous coordination with non-health sectors, a virtual education and information system and continuous training and educational supervision, as well as appropriate space, facilities and equipment, while the of needs of service recipients were classified based on services needed for age groups, namely, services for children, adolescents and young people, adult and middle-aged, elderly and others.
Conclusion: Identifying needs can lead to the optimal use of limited resources aiming at imparting applied education and training. The results of this research can be an effective step towards expansion based on the needs for mental health education and a great help in achieving the goals of this program in primary health care centers. Based on the results it is recommended to plan personnel training and revise the services based on the identified needs in order to increase the effectiveness of this program.
Somayeh Jalilvand, Atefeh Kachooei, Tayebeh Latifi, Mahdieh Motamedi‐rad, Mohammad Farahmand, Nasir Mohajel, Zabihollah Shoja,
Volume 21, Issue 2 (9-2023)
Volume 21, Issue 2 (9-2023)
Abstract
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2. Glass RI, Parashar UD, Bresee JS, Turcios R, Fischer TK, Widdowson M-A, et al. Rotavirus vaccines: current prospects and future challenges. The Lancet. 2006;368(9532):323-32.
3. Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerging infectious diseases. 2006;12(2):304.
4. Kargar M, Zare M, Najafi A. Molecular epidemiology of rotavirus strains circulating among children with gastroenteritis in Iran. Iranian journal of pediatrics. 2012;22(1):63.
5. Modares S, Rahbarimanesh AA, Karimi M, Modares S, Motamedirad M, Sohrabi A, et al. Electrophoretic RNA genomic profiles of rotavirus strains prevailing among hospitalized children with acute gastroenteritis in Tehran, Iran. 2008.
6. Shoja Z, Jalilvand S, Mokhtari-Azad T, Nategh R. Epidemiology of cocirculating human rotaviruses in Iran. The pediatric infectious disease journal. 2013;32(4):e178-e81.
7. Jalilvand S, Roohvand F, Arashkia A, Shoja Z. Update on Epidemiology and Circulating Genotypes of Rotavirus in Iranian Children With Severe Diarrhea: 1986-2015. Int J Travel Med Glob Health. 2018;6(1):7-10.
8. Desselberger U. Rotaviruses. Virus research. 2014;190:75-96.
9. http://rega.kuleuven.be/cev/ viralmetagenomics/virus-classification/ rcwg. updated 25 Mar, 2021 [.
10. Santos N, Hoshino Y. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Reviews in medical virology. 2005;15(1):29-56.
11. Banyai K, Laszlo B, Duque J, Steele AD, Nelson EA, Gentsch JR, et al. Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs. Vaccine. 2012;30(1):A122-30.
12. Doro R, Laszlo B, Martella V, Leshem E, Gentsch J, Parashar U, et al. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2014;28:446-61.
13. Mwanga MJ, Owor BE, Ochieng JB, Ngama MH, Ogwel B, Onyango C, et al. Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010-2018. BMC infectious diseases. 2020;20(1):1-12.
14. Matthijnssens J, Mino S, Papp H, Potgieter C, Novo L, Heylen E, et al. Complete molecular genome analyses of equine rotavirus A strains from different continents reveal several novel genotypes and a largely conserved genotype constellation. The Journal of general virology. 2012;93(Pt 4):866-75.
15. Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Banyai K, Estes MK, et al. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Archives of virology. 2008;153(8):1621-9.
16. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk Virus Infection and Disease Is Associated with ABO Histo-Blood Group Type. The Journal of Infectious Diseases. 2002;185(9):1335-7.
17. Carlsson B, Kindberg E, Buesa J, Rydell GE, Lidón MF, Montava R, et al. The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. PLoS One. 2009;4(5):e5593.
18. Tan M, Jiang X. Histo-blood group antigens: a common niche for norovirus and rotavirus. Expert reviews in molecular medicine. 2014;16.
19. Liu Y, Ramelot TA, Huang P, Liu Y, Li Z, Feizi T, et al. Glycan Specificity of P[19] Rotavirus and Comparison with Those of Related P Genotypes. J Virol. 2016;90(21):9983-96.
20. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, et al. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018;9(1):2631.
21. Yen C, Steiner CA, Barrett M, Curns AT, Hunter K, Wilson E, et al. Racial disparities in diarrhea-associated hospitalizations among children in five US States, before and after introduction of rotavirus vaccine. Vaccine. 2010;28(46):7423-6.
22. Payne DC, Currier RL, Staat MA, Sahni LC, Selvarangan R, Halasa NB, et al. Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States. JAMA pediatrics. 2015;169(11):1040-5.
23. Shoja Z, Jalilvand S, Mokhtari-Azad T, Nategh R. Epidemiology of cocirculating human rotaviruses in Iran. The Pediatric infectious disease journal. 2013;32(4):e178-81.
24. Shoja Z, Jalilvand S, Mollaei-Kandelous Y, Validi M. Epidemiology of viral gastroenteritis in Iran. The Pediatric infectious disease journal. 2014;33(2):218-20.
25. Kachooei A, Tava Koli A, Minaeian S, Hosseini M, Jalilvand S, Latifi T, et al. Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: Emergence of uncommon G9P [4] and G9P [8] rotavirus strains. Journal of medical virology. 2023;95(2):e2852.
26. Motamedi-Rad M, Farahmand M, Arashkia A, Jalilvand S, Shoja Z. VP7 and VP4 genotypes of rotaviruses cocirculating in Iran, 2015 to 2017: Comparison with cogent sequences of Rotarix and RotaTeq vaccine strains before their use for universal mass vaccination. Journal of medical virology. 2020;92(8):1110-23.
27. Jalilvand S, Afchangi A, Mohajel N, Roohvand F, Shoja Z. Diversity of VP7 genes of G1 rotaviruses isolated in Iran, 2009-2013. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2016;37:275-9.
28. Morozova OV, Sashina TA, Fomina SG, Novikova NA. Comparative characteristics of the VP7 and VP4 antigenic epitopes of the rotaviruses circulating in Russia (Nizhny Novgorod) and the Rotarix and RotaTeq vaccines. Archives of virology. 2015;160(7):1693-703.
29. Mouna BH, Hamida-Rebai MB, Heylen E, Zeller M, Moussa A, Kacem S, et al. Sequence and phylogenetic analyses of human rotavirus strains: comparison of VP7 and VP8( *) antigenic epitopes between Tunisian and vaccine strains before national rotavirus vaccine introduction. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2013;18:132-44.
30. Zeller M, Patton JT, Heylen E, De Coster S, Ciarlet M, Van Ranst M, et al. Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq. Journal of clinical microbiology. 2011; 50(3):966-976.
31. Hoshino Y, Jones RW, Ross J, Honma S, Santos N, Gentsch JR, et al. Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3. Journal of virology. 2004;78(14):7795-802.
32. Jin Q, Ward RL, Knowlton DR, Gabbay YB, Linhares AC, Rappaport R, et al. Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses. Archives of virology. 1996;141(11):2057-76.
33. Bányai K, Gentsch JR, Martella V, Bogdán Á, Havasi V, Kisfali P, et al. Trends in the epidemiology of human G1P [8] rotaviruses: a Hungarian study. The Journal of infectious diseases. 2009; 200 (1):S222-S7.
34. Magagula NB, Esona MD, Nyaga MM, Stucker KM, Halpin RA, Stockwell TB, et al. Whole genome analyses of G1P [8] rotavirus strains from vaccinated and non‐vaccinated South African children presenting with diarrhea. Journal of medical virology. 2015;87(1):79-101.
35. Kulkarni R, Arora R, Arora R, Chitambar SD. Sequence analysis of VP7 and VP4 genes of G1P [8] rotaviruses circulating among diarrhoeic children in Pune, India: A comparison with Rotarix and RotaTeq vaccine strains. Vaccine. 2014;32:A75-A83.
36. Zeller M, Patton JT, Heylen E, De Coster S, Ciarlet M, Van Ranst M, et al. Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in belgium and rotaviruses in rotarix™ and RotaTeq™. Journal of clinical microbiology. 2011:JCM. 05590-11.
37. Farahmand M, Jalilvand S, Arashkia A, Shahmahmoodi S, Afchangi A, Mollaei-Kandelous Y, et al. Association between circulating rotavirus genotypes and histo-blood group antigens (HBGAs) in the children hospitalized with acute gastroenteritis in Iran. Journal of medical virology. 2021;93(8):7.
38. Ayouni S, Sdiri-Loulizi K, de Rougemont A, Estienney M, Ambert-Balay K, Aho S, et al. Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia. Emerging infectious diseases. 2015;21(11):2055-8.
39. Nordgren J, Sharma S, Bucardo F, Nasir W, Gunaydin G, Ouermi D, et al. Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014;59(11):1567-73.
40. Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, et al. Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Molecular & cellular proteomics: MCP. 2014;13(11):2944-60.
41. Huang P, Xia M, Tan M, Zhong W, Wei C, Wang L, et al. Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. Journal of virology. 2012;86(9):4833-43.
42. Parker EP, Ramani S, Lopman BA, Church JA, Iturriza-Gomara M, Prendergast AJ, et al. Causes of impaired oral vaccine efficacy in developing countries. Future microbiology. 2018;13:97-118.
2. Glass RI, Parashar UD, Bresee JS, Turcios R, Fischer TK, Widdowson M-A, et al. Rotavirus vaccines: current prospects and future challenges. The Lancet. 2006;368(9532):323-32.
3. Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerging infectious diseases. 2006;12(2):304.
4. Kargar M, Zare M, Najafi A. Molecular epidemiology of rotavirus strains circulating among children with gastroenteritis in Iran. Iranian journal of pediatrics. 2012;22(1):63.
5. Modares S, Rahbarimanesh AA, Karimi M, Modares S, Motamedirad M, Sohrabi A, et al. Electrophoretic RNA genomic profiles of rotavirus strains prevailing among hospitalized children with acute gastroenteritis in Tehran, Iran. 2008.
6. Shoja Z, Jalilvand S, Mokhtari-Azad T, Nategh R. Epidemiology of cocirculating human rotaviruses in Iran. The pediatric infectious disease journal. 2013;32(4):e178-e81.
7. Jalilvand S, Roohvand F, Arashkia A, Shoja Z. Update on Epidemiology and Circulating Genotypes of Rotavirus in Iranian Children With Severe Diarrhea: 1986-2015. Int J Travel Med Glob Health. 2018;6(1):7-10.
8. Desselberger U. Rotaviruses. Virus research. 2014;190:75-96.
9. http://rega.kuleuven.be/cev/ viralmetagenomics/virus-classification/ rcwg. updated 25 Mar, 2021 [.
10. Santos N, Hoshino Y. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Reviews in medical virology. 2005;15(1):29-56.
11. Banyai K, Laszlo B, Duque J, Steele AD, Nelson EA, Gentsch JR, et al. Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs. Vaccine. 2012;30(1):A122-30.
12. Doro R, Laszlo B, Martella V, Leshem E, Gentsch J, Parashar U, et al. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2014;28:446-61.
13. Mwanga MJ, Owor BE, Ochieng JB, Ngama MH, Ogwel B, Onyango C, et al. Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010-2018. BMC infectious diseases. 2020;20(1):1-12.
14. Matthijnssens J, Mino S, Papp H, Potgieter C, Novo L, Heylen E, et al. Complete molecular genome analyses of equine rotavirus A strains from different continents reveal several novel genotypes and a largely conserved genotype constellation. The Journal of general virology. 2012;93(Pt 4):866-75.
15. Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Banyai K, Estes MK, et al. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Archives of virology. 2008;153(8):1621-9.
16. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk Virus Infection and Disease Is Associated with ABO Histo-Blood Group Type. The Journal of Infectious Diseases. 2002;185(9):1335-7.
17. Carlsson B, Kindberg E, Buesa J, Rydell GE, Lidón MF, Montava R, et al. The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. PLoS One. 2009;4(5):e5593.
18. Tan M, Jiang X. Histo-blood group antigens: a common niche for norovirus and rotavirus. Expert reviews in molecular medicine. 2014;16.
19. Liu Y, Ramelot TA, Huang P, Liu Y, Li Z, Feizi T, et al. Glycan Specificity of P[19] Rotavirus and Comparison with Those of Related P Genotypes. J Virol. 2016;90(21):9983-96.
20. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, et al. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018;9(1):2631.
21. Yen C, Steiner CA, Barrett M, Curns AT, Hunter K, Wilson E, et al. Racial disparities in diarrhea-associated hospitalizations among children in five US States, before and after introduction of rotavirus vaccine. Vaccine. 2010;28(46):7423-6.
22. Payne DC, Currier RL, Staat MA, Sahni LC, Selvarangan R, Halasa NB, et al. Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States. JAMA pediatrics. 2015;169(11):1040-5.
23. Shoja Z, Jalilvand S, Mokhtari-Azad T, Nategh R. Epidemiology of cocirculating human rotaviruses in Iran. The Pediatric infectious disease journal. 2013;32(4):e178-81.
24. Shoja Z, Jalilvand S, Mollaei-Kandelous Y, Validi M. Epidemiology of viral gastroenteritis in Iran. The Pediatric infectious disease journal. 2014;33(2):218-20.
25. Kachooei A, Tava Koli A, Minaeian S, Hosseini M, Jalilvand S, Latifi T, et al. Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: Emergence of uncommon G9P [4] and G9P [8] rotavirus strains. Journal of medical virology. 2023;95(2):e2852.
26. Motamedi-Rad M, Farahmand M, Arashkia A, Jalilvand S, Shoja Z. VP7 and VP4 genotypes of rotaviruses cocirculating in Iran, 2015 to 2017: Comparison with cogent sequences of Rotarix and RotaTeq vaccine strains before their use for universal mass vaccination. Journal of medical virology. 2020;92(8):1110-23.
27. Jalilvand S, Afchangi A, Mohajel N, Roohvand F, Shoja Z. Diversity of VP7 genes of G1 rotaviruses isolated in Iran, 2009-2013. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2016;37:275-9.
28. Morozova OV, Sashina TA, Fomina SG, Novikova NA. Comparative characteristics of the VP7 and VP4 antigenic epitopes of the rotaviruses circulating in Russia (Nizhny Novgorod) and the Rotarix and RotaTeq vaccines. Archives of virology. 2015;160(7):1693-703.
29. Mouna BH, Hamida-Rebai MB, Heylen E, Zeller M, Moussa A, Kacem S, et al. Sequence and phylogenetic analyses of human rotavirus strains: comparison of VP7 and VP8( *) antigenic epitopes between Tunisian and vaccine strains before national rotavirus vaccine introduction. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2013;18:132-44.
30. Zeller M, Patton JT, Heylen E, De Coster S, Ciarlet M, Van Ranst M, et al. Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq. Journal of clinical microbiology. 2011; 50(3):966-976.
31. Hoshino Y, Jones RW, Ross J, Honma S, Santos N, Gentsch JR, et al. Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3. Journal of virology. 2004;78(14):7795-802.
32. Jin Q, Ward RL, Knowlton DR, Gabbay YB, Linhares AC, Rappaport R, et al. Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses. Archives of virology. 1996;141(11):2057-76.
33. Bányai K, Gentsch JR, Martella V, Bogdán Á, Havasi V, Kisfali P, et al. Trends in the epidemiology of human G1P [8] rotaviruses: a Hungarian study. The Journal of infectious diseases. 2009; 200 (1):S222-S7.
34. Magagula NB, Esona MD, Nyaga MM, Stucker KM, Halpin RA, Stockwell TB, et al. Whole genome analyses of G1P [8] rotavirus strains from vaccinated and non‐vaccinated South African children presenting with diarrhea. Journal of medical virology. 2015;87(1):79-101.
35. Kulkarni R, Arora R, Arora R, Chitambar SD. Sequence analysis of VP7 and VP4 genes of G1P [8] rotaviruses circulating among diarrhoeic children in Pune, India: A comparison with Rotarix and RotaTeq vaccine strains. Vaccine. 2014;32:A75-A83.
36. Zeller M, Patton JT, Heylen E, De Coster S, Ciarlet M, Van Ranst M, et al. Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in belgium and rotaviruses in rotarix™ and RotaTeq™. Journal of clinical microbiology. 2011:JCM. 05590-11.
37. Farahmand M, Jalilvand S, Arashkia A, Shahmahmoodi S, Afchangi A, Mollaei-Kandelous Y, et al. Association between circulating rotavirus genotypes and histo-blood group antigens (HBGAs) in the children hospitalized with acute gastroenteritis in Iran. Journal of medical virology. 2021;93(8):7.
38. Ayouni S, Sdiri-Loulizi K, de Rougemont A, Estienney M, Ambert-Balay K, Aho S, et al. Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia. Emerging infectious diseases. 2015;21(11):2055-8.
39. Nordgren J, Sharma S, Bucardo F, Nasir W, Gunaydin G, Ouermi D, et al. Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014;59(11):1567-73.
40. Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, et al. Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Molecular & cellular proteomics: MCP. 2014;13(11):2944-60.
41. Huang P, Xia M, Tan M, Zhong W, Wei C, Wang L, et al. Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. Journal of virology. 2012;86(9):4833-43.
42. Parker EP, Ramani S, Lopman BA, Church JA, Iturriza-Gomara M, Prendergast AJ, et al. Causes of impaired oral vaccine efficacy in developing countries. Future microbiology. 2018;13:97-118.
Prevalence and Distribution of Common Rotavirus Genotypes in Iran and Comparing them with Vaccine Strains Before the Start of the National Vaccination Program
Somayeh Jalilvan1, Atefeh Kachooei2, Tayebeh Latifi3, Mahdieh Motamedi‐Rad4, Mohammad Farahmand3, Nasir Mohajel5, Zabihollah Shoja6*
1- Ph.D. Associate Professor, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Ph.D. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Ph.D. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4- MSc. Department of Virology, Pasteur Institute of Iran, Tehran, Iran
5- Ph.D. Assistant Professor, Department of Virology, Pasteur Institute of Iran, Tehran, Iran
6- Ph.D. Associate Professor, Department of Virology, Pasteur Institute of Iran, Tehran, Iran
* Corresponding author: zabihollahshoja@gmail.com, zshoja@alumnus.tums.ac.ir
Received: May 25, 2023 Accepted: Oct 11, 2023
ABSTRACT
Background and Aim: Since the discovery of rotaviruses in 1973, these viruses have been identified as one of the most important and common causes of diarrhea in infants and children all over the world. Before the introduction of rotavirus vaccination, this virus led to the death of more than 500,000 children in the world annually, which mainly occurs in developing countries. With the introduction of Rotarix and RotaTeq vaccines as well as ROTAVAC and ROTASIIL in the world, the death rate has decreased by 50%. Iran, like many countries, is in the period before rotavirus vaccination, and considering putting the rotavirus vaccine in the vaccination program is one of the priorities of the country's health system. Therefore, knowing the genotypes circulating in Iran in the past and recent years and their comparison with vaccine strains is very important. Our aim in the current study is to review the prevalence of rotavirus and its genotypes circulating in Iran and whether the existing vaccines based on the circulating strains in Iran can be effective.
Materials and Methods: Studies regard to the prevalence and genotypes of rotavirus in Iran were reviewed.
Results: G1P[8] genotype includes more than 50% of circulating genotypes. Non-G1P[8] genotypes, including G4P[8], G3P[8] and G9P[8], have also had a high frequency in some studies. In addition, in a recent study, it has been shown that the rare and uncommon genotype G9P[4] has been introduced as a common genotype.
Conclusion: Studies in Iran have shown that the country may face a change in the rotavirus genotype pattern in the future. This study can provide useful information to recommend appropriate policies for rotavirus vaccination before the start of the national vaccination program and may even change policies for the use of existing vaccines.
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