Mehdi Ahmadi, Farzad Amiri, Zahra Naghibifar, Mohammad Mehdi Mansouri, Armin Naghipour,
Volume 23, Issue 2 (9-2025)
Abstract
Background and Aim: Excessive use of antibiotics increases bacterial drug resistance in patients with diabetic foot ulcers. Therefore, the use of natural compounds as supplements may be effective in managing diabetic wound infections alongside conventional drugs. This study aimed to evaluate the effectiveness of Sarizh ointment (containing natural ingredients) on the healing of infected diabetic foot ulcers.
Materials and Methods: This single-center randomized clinical trial was conducted on patients with diabetic foot ulcers hospitalized in the infectious disease department of Imam Reza Hospital, Kermanshah. Microbial cultures were obtained from the foot ulcers of all patients using the punch method. Patients were randomly assigned to two groups: control and intervention. The control group received systemic antibiotics and a placebo dressing, while the intervention group received systemic antibiotics in addition to Sarizh herbal compounds as a supplement.
Results: A total of 30 patients with a mean age of 58.93 ± 6.15 years were included. The duration of hospitalization was 17.40 ± 3.06 days in the control group and 16.87 ± 3.52 days in the intervention group. The healing time was 17.34 ± 2.87 days in the control group and 12.06 ± 2.40 days in the intervention group. Sarizh ointment significantly reduced the healing time of diabetic foot ulcers (p = 0.001). Post-discharge bacterial cultures were negative, and complications such as redness, discharge, and pain at the wound site were similar between the two groups.
Conclusion: Sarizh ointment can be used as a complementary treatment alongside standard therapy to reduce healing time and promote wound recovery in patients with diabetic foot ulcers.
