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Physical Activity as a Popssible Predictor of Bone Mineral Density in the Hip and Lumbar Spine Areas in Women in Postmenopausal Years
Sajad Moradi, Leyla Khorrami , Fatemeh Zare, Sima Ali-Akbar, Zhila Maghbooli, Khadijeh Mirzaei,
Volume 14, Issue 4 (3-2017)
Abstract

Background and Aim: The role of physical activity in prevention of non-communicable diseases is now well known. The purpose of the present study was to find any possible association between physical activity and bone mineral density (BMD) in the hip and lumbar spine areas in women in postmenopausal years. 

Materials and Methods: This was a cross-sectional study including 254 postmenopausal women aged 46 to 78 years. Body composition and BMD were determined using the bioelectrical impedance analysis (BIA) and DEXA methods, respectively, and for physical activity measurement the International Physical Activity Questionnaire (IPAQ) was used.

Results: The distribution (%) of  the subjects according to the level of physical activity ─  inactive, moderate and active ─ was 39.7%, 47.6% and 12.5% respectively. There was a positive association between physical activity level and lumbar spine BMD (P = 0.03) in the 55-year-old or younger women. No association was found between physical activity level and the hip BMD(P>0.05).

Conclusion: Based on the findings it may be concluded  that physical activity level can be used as a predictor of bone mineral density in the lumbar spine area in women in postmenopausal years (≥55 years old). 


The Role of the SOST Gene in Identifying Postmenopausal Women at Risk for Low Bone Quality
Mohammad Bidkhori, Mahdi Akbarzadeh, Noushin Fahimfar, Bagher Larijani, Iraj Nabipour, Afshin Ostovar, Kourosh Holakouie-Naieni,
Volume 23, Issue 1 (6-2025)
Abstract
Background and Aim: The Trabecular Bone Score (TBS) is a novel tool for assessing bone microarchitecture and identifying individuals at risk for osteoporotic fractures. This study aimed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) of the SOST gene and TBS in Iranian postmenopausal women.
Materials and Methods: This study included 1/071 postmenopausal women from the Bushehr Elderly Health (BEH) Cohort study. Relationship between Seven independent SNPs in the SOST gene located on chromosome 17q21.31 were investigated with TBS L1–L4. Associations were tested using generalized linear models under additive, dominant, and recessive genetic models. A genetic score was also calculated by summing the weighted number of risk alleles based on the regression coefficients of the SNPs.
Results: After adjustment for age and Body Mass Index (BMI), SNP rs2023794-C showed a statistically significant association with TBS in the additive model (β = 0/ 03, P = 4/7×10⁻⁵, PFDR = 0/0003) and the dominant model (β = 0/033, P = 2/5×10⁻⁵, PFDR = 0/0003). Furthermore, higher genetic scores were positively associated with increased TBS values.
Conclusion: Our findings highlight the potential role of SOST gene variants and derived genetic score in predicting bone quality in postmenopausal women. These genes could aid in identifying individuals at higher risk of poor bone quality and in developing personalized osteoporosis prevention strategies.
 
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