Volume 82, Issue 9 (December 2024)
Tehran Univ Med J 2024, 82(9): 724-731 |
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Jamshidi F, Mirsalar M, Torabizadeh M, Zakerkish M, Rostami M, Moradi M. Vitamin D levels in maternal and umbilical cord blood
of premature and full-term infants at birth: a case-control study. Tehran Univ Med J 2024; 82 (9) :724-731
URL: http://tumj.tums.ac.ir/article-1-13350-en.html
URL: http://tumj.tums.ac.ir/article-1-13350-en.html
Farkhondeh Jamshidi *1 
, Maryam Mirsalar , Mehdi Torabizadeh2 , Mehrnoosh Zakerkish3 , Maryam Rostami4 , Maryam Moradi5
, Maryam Mirsalar , Mehdi Torabizadeh2 , Mehrnoosh Zakerkish3 , Maryam Rostami4 , Maryam Moradi5
1- Department of Forensic Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Department of Community Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Department of Community Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract: (850 Views)
Background: Vitamin D deficiency is associated with various complications, including preterm birth, low birth weight, and neonatal infections. This study aimed to measure the level of vitamin D in the umbilical cord blood of full-term and premature babies and consider the prevalence of vitamin D deficiency in pregnant women.
Methods: In this case-control study, maternal vitamin D levels and umbilical cord blood vitamin D levels were estimated in March 2023 at Imam Khomeini Hospital in Ahvaz. The information obtained from questionnaires and laboratory measurements was statistically analyzed. Two groups of term or preterm infants delivered vaginally were enrolled in this study. As part of routine delivery room protocols, 2 mL of umbilical cord blood was collected from each neonate in a non-heparinized tube. The results were determined, and the prevalence of vitamin D deficiency was determined. The samples were categorized into three groups based on vitamin D serum levels: less than 20 ng/ml (severe deficiency), 20-29 ng/ml (moderate deficiency), and higher than 30 ng/ml (normal group).
Results: In this study, 39 term infants (55.7%) and 31 preterm infants (44.3%) participated. The mean umbilical cord blood vitamin D levels were 44.15 ± 24.33 ng/mL in term infants and 30.98 ± 17.05 ng/mL in preterm infants. Similarly, maternal vitamin D levels averaged 17.09 ± 7.87 ng/mL for term pregnancies and 18.76 ± 6.6 ng/mL for preterm pregnancies. Preterm babies had higher odds of underlying diseases (OR: 2.31, 95% CI: 0.51-10.53). Multivitamin consumption was more prevalent among mothers of premature babies (71%). No significant differences in vitamin D levels were found between term and preterm babies or their mothers (P > 0.05).
Conclusion: This study highlights the importance of multivitamin consumption among pregnant women, particularly those at risk of preterm delivery. The increased likelihood of underlying conditions and delayed recovery of vitamin D levels in preterm infants underscores the need for targeted interventions. Moreover, healthcare providers should emphasize vitamin D supplementation and monitoring.
Methods: In this case-control study, maternal vitamin D levels and umbilical cord blood vitamin D levels were estimated in March 2023 at Imam Khomeini Hospital in Ahvaz. The information obtained from questionnaires and laboratory measurements was statistically analyzed. Two groups of term or preterm infants delivered vaginally were enrolled in this study. As part of routine delivery room protocols, 2 mL of umbilical cord blood was collected from each neonate in a non-heparinized tube. The results were determined, and the prevalence of vitamin D deficiency was determined. The samples were categorized into three groups based on vitamin D serum levels: less than 20 ng/ml (severe deficiency), 20-29 ng/ml (moderate deficiency), and higher than 30 ng/ml (normal group).
Results: In this study, 39 term infants (55.7%) and 31 preterm infants (44.3%) participated. The mean umbilical cord blood vitamin D levels were 44.15 ± 24.33 ng/mL in term infants and 30.98 ± 17.05 ng/mL in preterm infants. Similarly, maternal vitamin D levels averaged 17.09 ± 7.87 ng/mL for term pregnancies and 18.76 ± 6.6 ng/mL for preterm pregnancies. Preterm babies had higher odds of underlying diseases (OR: 2.31, 95% CI: 0.51-10.53). Multivitamin consumption was more prevalent among mothers of premature babies (71%). No significant differences in vitamin D levels were found between term and preterm babies or their mothers (P > 0.05).
Conclusion: This study highlights the importance of multivitamin consumption among pregnant women, particularly those at risk of preterm delivery. The increased likelihood of underlying conditions and delayed recovery of vitamin D levels in preterm infants underscores the need for targeted interventions. Moreover, healthcare providers should emphasize vitamin D supplementation and monitoring.
Type of Study: Original Article |
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