دوره 53، شماره 1 - ( 1-1374 )
جلد 53 شماره 1 صفحات 35-31 |
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Mohyeddin M, Khosravi F, Nikbin B. Distribution of HLA antigents in Turkman race. Tehran Univ Med J 1995; 53 (1) :31-35
URL: http://tumj.tums.ac.ir/article-1-1702-fa.html
URL: http://tumj.tums.ac.ir/article-1-1702-fa.html
محی الدین ماندانا، خسروی فریده، نیک بین بهروز. انتشار آنتی ژن های HLA در نژاد ترکمن. مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران. 1374; 53 (1) :31-35
چکیده: (5478 مشاهده)
The Turkmans are one of the Iranian ethnic population. HLA typing (class I and II) was performed in this population. The data obtained from this study was compared with different populations of the world. We observed that the Turkman population is most similar to the Northern chinese and Uigur population. The distributions of HLA antigens in Turkmans are somewhat between Iranian population, Northern chinese and Uigur population. Natural selection and gene alteration select the people who could better adopt themselves with new conditions. Investigation of Turkman's HLA in comparison with Iranian's HLA reveals more details in genetics of Behcet's disease. Behcet's disease is very rare in Turkmans (index 0.5) whereas its frequency is high in other Iranians and Northern chinese. Distribution of susceptible antigens like B5 is the same in Turkmans and Northern chinese (19.5%) but much higher in other Iranians, whereas B35 have almost the same distribution in Turkmans and Iranians (37% and 33% respectively). DQW1 and CW4 antigens which were suspected to have a negative association with Behcet's disease are the most frequent antigens in Turkmans.
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