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Background: Defective sperm function is now recognized as
one of the most important causes of male infertility. Seminal plasma possesses
a rich source of different enzymatic and
non-enzymatic antioxidants such as vitamin C (ascorbic
acid) that protect spermatozoa against oxidative stress as one of the mediators
of infertility causing sperm dysfunction and low sperm quality. The
aim of this study was investigation of seminal total antioxidant capacity and determination
of vitamin C effects on sperm
motility.
Methods: We designed a case-control study with a total
subject of 62 males. Sperm
parameters were analyzed according to World
Health Organization
guidelines (WHO, 1999).
Total antioxidant capacity and vitamin C
level of seminal plasma were measured in the 32
normozoospermic as the control group and 32
asthenospermic men as the case group using FRAP
(Ferric Reducing of Antioxidants
Powers)
and RP-HPLC (Reverse Phase
High Performance
Liquid Chromatography)
methods, respectively.
Results: Our results indicated that total antioxidant
capacity levels in the seminal plasma of asthenospermic men were significantly
lower than healthy men (p=0.002).
In addition, we found a positive correlation
between reduced total antioxidant capacity levels and low sperm motility. Vitamin
C levels of seminal plasma in asthenospermic men
were statistically lower than control men (p=0.01).
Conclusions: It is suggested that asthenospermia could be
related to an antioxidant deficiency or it&aposs reduction.
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