1- Department of exercise physiology, Zand institute of higher education, Shiraz, Iran
2- Department of exercise physiology, Zand institute of higher education, Shiraz, Iran ,erahimi58@gmail.com
3- Dpartment of Sports Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of exercise physiology, Zand institute of higher education, Shiraz, Iran ,
3- Dpartment of Sports Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract: (97 Views)
Background: Metabolic syndrome is characterized by a cluster of conditions such as abdominal obesity, high triglycerides, high blood pressure, high blood sugar, and low levels of healthy fat. Therefore, this study aimed to investigate the effect of endurance training on PGC1α protein content, glycosylated hemoglobin and metabolic syndrome indices in obese rats with type 2 diabetes.
Methods: Eighteen male Wistar rats with an average weight of 200±20 g were selected and placed on a high-fat diet for four weeks. Then 12 rats were randomly selected and induced type 2 diabetes by injecting nicotinamide (110 mg/kg) and streptozotocin (50 mg/kg) solutions. Diabetic rats were randomly divided into two groups of training and control patients. The samples of the training group performed endurance training on the treadmill for 8 weeks and 5 sessions every week with an intensity of about 50 to 70% of the maximum speed. 48 hours after the last training session, mice were sacrificed and variables were measured. To analyse the data, one-way ANOVA and Tukey's post hoc tests were performed in SPSS software version 29.
Findings: Endurance training led to a significant decrease in fasting blood sugar levels, HbA1c and triglyceride levels (P=0.0001). On the other hand, it did not show any effect on HDL levels (P=0.087). On the contrary, it led to an increase in the intracellular amount of PGC-1α (P=0.0001).
Conclusion: The results show that endurance training can be considered as an adjuvant drug by regulating the factors related to metabolic syndrome.
Methods: Eighteen male Wistar rats with an average weight of 200±20 g were selected and placed on a high-fat diet for four weeks. Then 12 rats were randomly selected and induced type 2 diabetes by injecting nicotinamide (110 mg/kg) and streptozotocin (50 mg/kg) solutions. Diabetic rats were randomly divided into two groups of training and control patients. The samples of the training group performed endurance training on the treadmill for 8 weeks and 5 sessions every week with an intensity of about 50 to 70% of the maximum speed. 48 hours after the last training session, mice were sacrificed and variables were measured. To analyse the data, one-way ANOVA and Tukey's post hoc tests were performed in SPSS software version 29.
Findings: Endurance training led to a significant decrease in fasting blood sugar levels, HbA1c and triglyceride levels (P=0.0001). On the other hand, it did not show any effect on HDL levels (P=0.087). On the contrary, it led to an increase in the intracellular amount of PGC-1α (P=0.0001).
Conclusion: The results show that endurance training can be considered as an adjuvant drug by regulating the factors related to metabolic syndrome.
Keywords: Endurance Training, Metabolic Syndrome, Type 2 Diabetes, HbA1C, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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